Faculty of Health Sciences: Recent submissions
Now showing items 921-940 of 2404
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Structural exploration of synthetic chromones as selective MAO-B inhibitors: a mini review
(Bentham Science, 2017)Aim and Objective: Specific inhibitors of monoamine oxidase (MAO)-B are considered useful therapeutic agents in targeting neurological disorders like Alzheimer's and Parkinson's diseases. Due to the academic challenge of ... -
Crystal form conversion of nevirapine solvates subjected to elevated temperature and humidity: a qualitative study
(Ingenta, 2017)Some known nevirapine solvates have been reported to undergo solvent exchange in aqueous media to form a stable hemihydrate. This study aimed to determine the effects of atmospheric moisture on said nevirapine solvates and ... -
HIV stigma experiences and stigmatisation before and after a HIV stigma-reduction community “hub” intervention
(Taylor & Francis, 2017)This study sought to explore, describe and determine whether an HIV stigma-reduction community “hub” intervention would change the HIV stigma experiences of people living with HIV (PLWH) and the stigmatisation by the ... -
Validation of the child and youth resilience measure among South African adolescents
(Public Library of Science, 2017)Resilience is a dynamic, interactive process between resources that contribute to safeguarding a person and the adversities they experience. Within this promotional framework of resilience, this study sought to validate ... -
Occupational respiratory exposure to platinum group metals: a review and recommendations
(ACS, 2017)Platinum group metals (PGMs) is a group of metals that include platinum, palladium, rhodium, ruthenium, iridium, and osmium. Occupational respiratory exposure to platinum has been reported since 1945, but studies investigating ... -
Three-year change in endothelin-1 and markers of vascular remodelling in a bi-ethnic South African cohort: the SABPA study
(Springer Nature, 2017)South Africans are at high risk for developing cardiovascular disease. Endothelin-1 is known for its vasoconstrictive properties and its ability to contribute to vascular structural changes. In this study we investigated ... -
Protein and fat meal content increase insulin requirement in children with type 1 diabetes: role of duration of diabetes
(Elsevier, 2017)Background and objective Hyperglycaemia remains a challenge in type 1 diabetes since current regimes used to determine meal insulin requirements prove to be ineffective. This is particularly problematic for meals containing ... -
The antimicrobial peptide nisin Z induces selective toxicity and apoptotic cell death in cultured melanoma cells
(Elsevier, 2018)Reprogramming of cellular metabolism is now considered one of the hallmarks of cancer. Most malignant cells Reprogramming of cellular metabolism is now considered one of the hallmarks of cancer. Most malignant cells present ... -
Topical delivery of Withania somnifera crude extracts in niosomes and solid lipid nanoparticles
(Medknow, 2017)Background: Withania somnifera is a medicinal plant native to India and is known to have anticancer properties. It has been investigated for its anti-melanoma properties, and since melanoma presents on the skin, it is ... -
Associations between dietary salt, potassium and blood pressure in South African adults: WHO SAGE Wave 2 Salt & Tobacco
(Elsevier, 2017)Background & aims In June 2016, South Africa implemented legislation mandating maximum sodium levels in a range of processed foods with a goal of reducing population salt intake and disease burden from hypertension. Our ... -
GLP in safety pharmacology studies: report card after 15 years
(Elsevier, 2017)The pivotal role of safety pharmacology in the safety testing of new drugs is now well established, having received a large impetus through the regulatory requirement of this type of study and the appearance of the ICHS7A ... -
Socio-demographic and lifestyle factors predict 5-year changes in adiposity among a group of black South African adults
(MDPI, 2017)The rising prevalence of obesity and excessive adiposity are global public health concerns. Understanding determinants of changes in adiposity over time is critical for informing effective evidence-based prevention or ... -
The health benefits and constraints of exercise therapy for wheelchair users: a clinical commentary
(AOSIS, 2017)Background: There are approximately 1 billion people living with chronic lower limb disability, many of whom are wheelchair users. Objectives: Review cardiometabolic and neuromuscular risk profiles of wheelchair ... -
Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016
(Elsevier, 2017)Background The UN’s Sustainable Development Goals (SDGs) are grounded in the global ambition of “leaving no one behind”. Understanding today’s gains and gaps for the health-related SDGs is essential for decision makers ... -
Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016
(Elsevier, 2017)Background Measurement of changes in health across locations is useful to compare and contrast changing epidemiological patterns against health system performance and identify specific needs for resource allocation ... -
Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease Study 2016
(Elsevier, 2017)Background Monitoring levels and trends in premature mortality is crucial to understanding how societies can address prominent sources of early death. The Global Burden of Disease 2016 Study (GBD 2016) provides a comprehensive ... -
Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016
(Elsevier, 2017)Background The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of risk factor exposure and attributable burden of disease. By providing estimates over a long ... -
Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: a systematic analysis for the Global Burden of Disease Study 2016
(Elsevier, 2017)Background Detailed assessments of mortality patterns, particularly age-specific mortality, represent a crucial input that enables health systems to target interventions to specific populations. Understanding how all-cause ... -
A simple and cost-effective HPLC-UV method for the detection of levetiracetam in plasma/serum of patients with epilepsy
(Wiley, 2017)A simple, fast and cost-effective method was developed and validated for the determination of levetiracetam (LEV) in plasma/serum of patients using high performance liquid chromatography (HPLC) with ultraviolet detection. ... -
Synthesis, in vitro evaluation, and 68Ga-radiolabeling of CDP1 toward PET/CT imaging of bacterial infection
(Wiley, 2017)Bacterial infections are a major concern in the human health sector due to poor diagnosis and development of multidrug-resistant strains. PET/CT provides a means for the non-invasive detection and localization of the ...
