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    The antimicrobial peptide nisin Z induces selective toxicity and apoptotic cell death in cultured melanoma cells

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    Date
    2018
    Author
    Lewies, Angélique
    Wentzel, Johannes Frederik
    Van Dyk, Hayley
    Du Plessis, Lissinda Hester
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    Abstract
    Reprogramming of cellular metabolism is now considered one of the hallmarks of cancer. Most malignant cells Reprogramming of cellular metabolism is now considered one of the hallmarks of cancer. Most malignant cells present with altered energy metabolism which is associated with elevated reactive oxygen species (ROS) generation. This is also evident for melanoma, the leading cause of skin cancer related deaths. Altered mechanisms affecting mitochondrial bioenergetics pose attractive targets for novel anti-cancer therapies. Antimicrobial peptides have been shown to exhibit selective anti-cancer activities. In this study, the anti-melanoma potential of the antimicrobial peptide, nisin Z, was evaluated in vitro. Nisin Z was shown to induce selective toxicity in melanoma cells compared to non-malignant keratinocytes. Furthermore, nisin Z was shown to negatively affect the energy metabolism (glycolysis and mitochondrial respiration) of melanoma cells, increase reactive oxygen species generation and cause apoptosis. Results also indicate that nisin Z can decrease the invasion and proliferation of melanoma cells demonstrating its potential use against metastasis associated with melanoma. As nisin Z seems to place a considerable extra burden on the energy metabolism of melanoma cells, combination therapies with known anti-melanoma agents may be effective treatment options
    URI
    http://hdl.handle.net/10394/25958
    https://www.sciencedirect.com/science/article/pii/S0300908417302614
    https://doi.org/10.1016/j.biochi.2017.10.009
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    • Faculty of Natural and Agricultural Sciences [4855]

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