Browsing Faculty of Health Sciences by Issue Date
Now showing items 1-20 of 2369
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Variable-temperature X-ray powder diffraction analysis of the crystal transformation of the pharmaceutically preferred polymorph C of mebendazole
(Elsevier, 2005)Mebendazole is a common benzimidazole anthelmintic that is water insoluble. It is reported to exist in three different polymorphic forms in the solid state, i.e. polymorph A, B and C. Form C is the pharmaceutically preferred ... -
Synthesis and transdermal properties of acetylsalicylic acid and selected esters
(Elsevier, 2006)The primary aim of this study was to determine the transdermal penetration of acetylsalicylic acid and some of its derivatives, to establish a correlation, if any, with selected physicochemical properties and to determine ... -
Prevalence of drug-drug interactions of antiretroviral agents in the private health care sector in South Africa
(Health & Medical Publishing Group, 2008)Objectives. Human immunodefiency virus (HIV) infection can be effectively treated with highly active antiretroviral therapy (HAART), requiring concomitant administration of three to four different agents, often with a ... -
Stereotypic behaviour in the deer mouse: pharmacological validation and relevance for obsessive compulsive disorder
(Elsevier, 2008)Stereotypy is an important manifestation of obsessive compulsive disorder (OCD). OCD involves disturbed serotonin and dopamine pathways, and demonstrates a selective response to serotonin reuptake inhibitors (SRI), with ... -
Die invloed van fisieke-aktiwiteitsdeelname op die verband tussen die koronêrerisiko-indeks en enkele demografiese konstrukte by NG-predikante in Suid-Afrika
(University of South Africa, the Department of Practical theology, 2008)The objective of this study was to determine the interaction of physical activity on the relationship between coronary risk index and years of service, congregation size, co-ministership and congregation type of Dutch ... -
Studies on cellular resilience and adaptation following acute and repetitive exposure to ozone in cultured human epithelial (HeLa) cells
(Taylor & Francis, 2008)Ozone is used to treat several medical conditions, while the underlying mechanisms of action are sometimes poorly understood. In the current study, we exposed cultured human epithelial (HeLa) cells acutely and repeatedly ... -
Effect of penetration modifiers on the dermal and transdermal delivery of drugs and cosmetic active ingredients
(Karger, 2008)In this study the effect of 2 penetration modifiers, dimethyl isosorbide (DMI) and diethylene glycol monoethyl ether (DGME) on the skin delivery of hydroquinone (HQ), salicylic acid (SA) and octadecenedioic acid (DIOIC) ... -
Genetic polymorphisms of beta(2)- and beta(3)- adrenergic receptor genes associated with characteristics of the metabolic syndrome in black South African women
(Thieme, 2008)Background: Genetic variation in the β2 (ADRB2) and β3 (ADRB3) adrenergic receptor genes are associated with obesity and insulin resistance. To further elucidate the role of these genes in the pathophysiology of obesity ... -
Bone resorption and environmental exposure to cadmium in women: a population study
(National Institute of Environmetal Health Sciences (NIEHS), 2008)Background: Environmental exposure to cadmium decreases bone density indirectly through hypercalciuria resulting from renal tubular dysfunction. Objective: We sought evidence for a direct osteotoxic effect of cadmium in ... -
Development of microporous drug-releasing films cast from artificial nanosized latexes of poly (styrebe-co-methyl methacrylate) or poly (styrene-co-ethyl methacylate)
(Elsevier, 2008)Two sets of copolymers comprising of styrene and either methyl or ethyl methacrylate as comonomer were conveniently synthesized by microemulsion copolymerization. The purified materials were characterized by GPC-MALLS and ... -
Hyperuricaemia is an independent factor for the metabolic syndrome in a sub-Saharan African population: a factor analysis
(Elsevier, 2008)Objective To assess the risk factor pattern of the metabolic syndrome and its association with insulin resistance and hyperuricaemia in a sub-Saharan African population with different levels of urbanisation. Methods Four ... -
Investigating the potential neuroprotective effects of statins on DNA damage in mouse striatium
(Elsevier, 2008)We investigated the protective effect of pravastatin, simvastatin and atorvastatin on striatal DNA damage as a potential method to conserve and protect the nigrostriatal neurons. C57Bl/J6 mice were treated with combinations ... -
Stress and re-stress increases conditioned taste aversion learning in rats: possible frontal cortical and hippocampal muscarinic receptor involvement
(Elsevier, 2008)Symptoms of posttraumatic stress disorder are often precipitated by sensory cues in the form of visual, auditory, olfactory and gustatory “flashbacks” resulting in enhanced fear-memory consolidation and the characteristic ... -
Medicinal chemistry of polycyclic cage compounds in drug discovery research
(Springer, 2008)Saturated polycyclic hydrocarbon structures such as the monocyclic octane, bicylic norbornane and tricyclic adamantane have attracted the attention of several research groups since the 1930s. In the 1950s the synthesis of ... -
N, N-Bis (trifluoromethylquinoline-4-yl)diamino alkanes: synthesis and antimalarial activity
(Bentham Science, 2008)A series of N,N-bis(trifluoromethylquinolin-4-yl)- and N,N-bis[2,8-bis(trifluoromethyl)quinolin-4-yl] diamino alkane and piperazine derivatives were synthesised by employing a simple and rapid displacement reaction of the ... -
Synthesis, complete 1H and 13C NMR assignment and crystal structure of novel epoxide derivatives of cytochalasin B
(University of Stellenbosch, 2008) -
Intestinal drug absorption enhancers: synergistic effects of combinations
(Taylor & Francis, 2008)Although many absorption enhancers have been investigated, very few are used clinically. A need exists therefore for more effective absorption enhancers. The drug-absorption-enhancing effects of combinations of N-trimethyl ... -
Solvent inclusion by the anti-HIV drug nevirapine: X-ray structures and thermal decomposition of representative solvates
(ACS, 2008)Five crystalline solvates of the anti-HIV drug Nevirapine (N), with compositions N·(ethyl acetate)0.5 (1), N·(dichloromethane)0.5 (2), N·(toluene)0.5 (3), N·(water)0.5 (4), and N·(1,4-dioxane)1.5 (5), were isolated and ... -
Policy makers' perceptions and attitutdes regarding incorporation of traditional healers into the national health care delivery system
(Democratic Nursing Organisation of South Africa (DENOSA), 2008)
