Circulating cytokines and risk of developing hypertension: A systematic review and meta-analysis
| dc.contributor.author | Elisabetta Caiazzo et al | |
| dc.date.accessioned | 2026-01-20T07:08:29Z | |
| dc.date.issued | 2024 | |
| dc.description | a School of Infection & Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK b Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy c School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK d Department of Periodontology, Prophylaxis and Oral Medicine, Jagiellonian University, Krakow, Poland e Department of Rheumatology and Immunology, Jagiellonian University Medical College, Kracow, Poland f School of Cardiovascular and Metabolic Health, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK g SA MRC/Wits Developmental Pathways for Health Research Unit (DPHRU), School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, South Africa h Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa i MRC Research Unit: Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa j The George Institute for Global Health, Sydney, Australia k School of Population Health, University of New South Wales, Sydney, Australia l Department of Public Health, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy m Africa-Europe Cluster of Research Excellence in Non-Communicable Diseases & Multimorbidity, African Research Universities Alliance (ARUA) & The Guild of European Research-intensive Universities, South Africa n Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK o Department of Internal and Agricultural Medicine and Omicron Medical Genomics Laboratory, Jagiellonian University Medical College, Krakow, Poland | |
| dc.description.abstract | Background: Immune responses play a significant role in hypertension, though the importance of key inflammatory mediators remains to be defined. We used a systematic literature review and meta-analysis to study the associations between key cytokines and incident hypertension. Methods: We performed a systematic search of Pubmed/Medline, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL), for peer-reviewed studies published up to August 2022. Incident hypertension was defined as systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg and/or the use of antihypertensive medications. Random effects meta-analyses were used to calculate pooled hazard ratios (HRs)/risk ratios (RRs) and 95% confidence intervals by cytokine levels (highest vs. lowest quartile). | |
| dc.identifier.citation | Caiazzo, E., Sharma, M., Rezig, A.O., Morsy, M.I., Czesnikiewicz-Guzik, M., Ialenti, A., Sulicka-Grodzicka, J., Pellicori, P., Crouch, S.H., Schutte, A.E. and Bruzzese, D., 2024. Circulating cytokines and risk of developing hypertension: A systematic review and meta-analysis. Pharmacological Research, 200, p.107050. | |
| dc.identifier.uri | http://hdl.handle.net/10394/45422 | |
| dc.language.iso | en | |
| dc.publisher | Elsevier B.V. | |
| dc.subject | Cytokines Incident hypertension Risk Systematic review Meta-analysis | |
| dc.title | Circulating cytokines and risk of developing hypertension: A systematic review and meta-analysis | |
| dc.type | Article |