Circulating cytokines and risk of developing hypertension: A systematic review and meta-analysis
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Elsevier B.V.
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Abstract
Background: Immune responses play a significant role in hypertension, though the importance of key inflammatory mediators remains to be defined. We used a systematic literature review and meta-analysis to study the
associations between key cytokines and incident hypertension.
Methods: We performed a systematic search of Pubmed/Medline, Embase, Web of Science, and the Cochrane
Central Register of Controlled Trials (CENTRAL), for peer-reviewed studies published up to August 2022. Incident hypertension was defined as systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg
and/or the use of antihypertensive medications. Random effects meta-analyses were used to calculate pooled
hazard ratios (HRs)/risk ratios (RRs) and 95% confidence intervals by cytokine levels (highest vs. lowest
quartile).
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a School of Infection & Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK b Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy c School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK d Department of Periodontology, Prophylaxis and Oral Medicine, Jagiellonian University, Krakow, Poland e Department of Rheumatology and Immunology, Jagiellonian University Medical College, Kracow, Poland f School of Cardiovascular and Metabolic Health, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK g SA MRC/Wits Developmental Pathways for Health Research Unit (DPHRU), School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand,
South Africa h Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa i MRC Research Unit: Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa j The George Institute for Global Health, Sydney, Australia k School of Population Health, University of New South Wales, Sydney, Australia l Department of Public Health, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy m Africa-Europe Cluster of Research Excellence in Non-Communicable Diseases & Multimorbidity, African Research Universities Alliance (ARUA) & The Guild of
European Research-intensive Universities, South Africa n Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK o Department of Internal and Agricultural Medicine and Omicron Medical Genomics Laboratory, Jagiellonian University Medical College, Krakow, Poland
Citation
Caiazzo, E., Sharma, M., Rezig, A.O., Morsy, M.I., Czesnikiewicz-Guzik, M., Ialenti, A., Sulicka-Grodzicka, J., Pellicori, P., Crouch, S.H., Schutte, A.E. and Bruzzese, D., 2024. Circulating cytokines and risk of developing hypertension: A systematic review and meta-analysis. Pharmacological Research, 200, p.107050.