Browsing Health Sciences by Subject "Pharmacokinetics"
Now showing items 1-7 of 7
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Artemisinin–quinoline hybrids : design, synthesis and antimalarial activity
(North-West University, 2013)Introduction - Malaria is a major global health problem, with more than 500 million reported cases and at least 1 million deaths each year. The main problem with malaria control is the emerging drug resistance. Plasmodium ... -
A clinical investigation into the bioavailability of a peroral cannabinoid-Pheroid® formulation
(North-West University (South-Africa), 2020)The therapeutic advantages of pure Cannabidiol (CBD), a phytocannabinoid isolated from the Cannabis sativa L. plant, are emphasised by the growing use of CBD in numerous conditions ranging from supplementary to the treatment ... -
The development and evaluation of a novel hybrid PLGA nanoparticle-Pheroid® with the potential to improve tuberculosis therapy
(North-West University, Potchefstroom Campus, 2018)The development of drug delivery technologies has the potential to bring both therapeutic and commercial value to future healthcare products. Drug delivery technologies are transport vehicles that help overcome the ... -
Enhancement of nasal drug delivery by means of beneficial pharmacokinetic interactions
(North-West University (South-Africa), 2020)Drug products and dosage forms are seldom taken in complete isolation. The possibility exist to ingest drugs together with foods, herbs, dietary supplements and/or other drugs, which may result in pharmacokinetic or ... -
Evaluation of the oral delivery of goserelin with Pheroid® technology
(North-West University (South-Africa), 2019)The therapeutic amphiphilic peptide, goserelin, being investigated in these studies, is a type of hormone therapy generally used in addition to standard adjuvant therapy. Goserelin serves as treatment for numerous ... -
The in vitro and in vivo pharmacokinetic parameters of polylactic–co–glycolic acid nanoparticles encapsulating anti–tuberculosis drugs
(North-West University, 2012)Tuberculosis (TB) is an infectious, deadly disease, caused by Mycobacterium tuberculosis (M.tb). In 2010, there were 8,8 million incident cases of TB globally. South Africa currently has the third highest TB incident ... -
Population pharmacokinetic and pharmacodynamic study of efavirenz in HIV–1–infected children treated with first line antiretroviral therapy in South Africa
(North-West University, 2011)Highly active antiretroviral therapy (HAART) has improved the life expectancy of HIV–1–infected patients dramatically since it was launched in 1996, but there are still many challenges in the provision of HAART, especially ...