Health Sciences
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Novel multi-mechanism neuroprotectice coumarin conjugates as disease-modifying therapies for Alzheimer's disease
(North-West University (South-Africa). Potchefstroom Campus, 2016)Alzheimer’s Disease (AD) is the most prominent of all the types of dementias. It’s a neurodegenerative disease that affects the central nervous system (CNS) and general symptoms includes a decline in cognitive abilities ... -
Psycho-education with individuals diagnosed with a personality disorder : a systematic review
(North-West University (South-Africa). Potchefstroom Campus, 2016)Much research and knowledge has been generated on personality disorders. Less information is available on the treatment and the effectiveness of treatment for personality disorders. Very little has been written about the ... -
Towards a responsible food-based dietary guideline for alcohol consumption for South Africa
(North-West University (South-Africa). Potchefstroom Campus, 2009)Alcohol abuse in South Africa is a major problem. It has negative social and health consequences. The social effects include a contribution to high levels of crime, road accidents, intentional and unintentional ... -
Salutogenic versus pathogenic metaphorical language usage in South Africa's National HIV/AIDS Education Policy
(North-West University (South-Africa). Vanderbijlpark Campus, 2019-04)This study explored the use of metaphorical language in South Africa’s national HIV/AIDS education policy, and to what extent the metaphorical messages conveyed about HIV and AIDS in the policy are essentially health ... -
Comparative study of N-acetyl cysteine and an experimental xanthone compound on behavioral, immune-inflammatory and redox biomarkers of depression in the Flinders sensitive line rat
(North-West University (South-Africa). Potchefstroom Campus, 2016)The focus of determining the underlying pathophysiological pathways of major depressive disorder (MDD) has shifted from identifying one single hypothesis to the incorporation of various aspects of the disease. Increasing ... -
Concordance of goals and meaning in the family domain: Associations with demographic variables and well-being
(North-West University (South-Africa). Potchefstroom Campus, 2019)Goals and meaning as important constructs of eudaimonic well-being have been studied separately, but research is scant on the concordance of goals and meaning, especially in specific life domains. The aim of this study was ... -
HIV-stigma reduction and responsible disclosure management in a primary health care setting
(North-West University (South-Africa). Potchefstroom Campus, 2018)Worldwide human immunodeficiency virus (HIV) related stigma is viewed as a complex concept with far reaching consequences for people living with HIV (PLWH), people living close (PLC) to PLWH, communities in different ... -
The occurrence of drug related problems in a primary health care setting : a pharmaceutical care approach
(North-West University (South-Africa). Potchefstroom Campus, 2002)The worldwide trend in the pharmacy profession is towards pharmaceutical care. According to the latest views the provision of pharmaceutical care by pharmacists is the way forward for the profession in South Africa. P ... -
Combined first line anti-TB drugs: new insights into stability
(North-West University (South-Africa). Potchefstroom Campus, 2019-05)Tuberculosis (TB) is the most prevalent infectious cause of death globally, affecting approximately one-third of the world’s population (Borgdoff et al., 2002). Mycobacterium tuberculosis (M. tuberculosis) is spread ... -
Bipolar disorder in the South African private health sector: Longitudinal analysis of prevalence, comorbidities and prescribing patterns
(North-West University (South-Africa).Potchefstroom Campus, 2019-05)Bipolar disorder (BD) is a chronic affective disorder characterised by mood changes, fluctuating between depressive symptoms and manic symptoms. It is one of the psychiatric illnesses that have contributed to the chronic ... -
Development of vitamin C and E fixed-dose combination, multiple-unit, solid oral delivery systems
(North-West University (South-Africa). Potchefstroom Campus, 2019-05)Oral drug delivery is one of the most preferred and user-friendly routes of drug administration, however, vitamin C and vitamin E have poor and unreliable bioavailability at doses intended for anti-oxidant effects. This ... -
Coping, copeptin and cardiac stress : The SABPA study
(North-West University (South-Africa). Potchefstroom Campus, 2019-05)Coping met emosionele stres kan óf effektief wees vir die neutralisering van stres óf dit kan negatiewe kardiovaskulêre uitkomste fasiliteer. Verdedigende-coping (DefS) en sosiale ondersteunings-coping is op effektiewe ... -
Interpretation of maximum absorbance data obtained from turbidimetry in plasma samples with varying fibrinogen concentration
(North-West University (South-Africa). Potchefstroom Campus, 2019-05)Cardiovascular disease (CVD) has become South Africa’s second largest cause of death. CVD is often associated with vascular injury, which initiates the coagulation cascade and formation of an occlusive or non-occlusive ... -
Research methods for conducting pharmacoepidemiological studies using medicines claims data
(North-West University (South-Africa). Potchefstroom Campus, 2019-05)This study aimed to evaluate the appropriate use of various research methods in pharmacoepidemiological studies using a South African medicines claims database. A literature review was carried out to conceptualise ... -
Concordance of goals and meaning in the intrapersonal life domain: Associations with demographic variables and well-being
(North-West University (South-Africa). Potchefstroom Campus, 2019-05)Goals and meaning are important facets of eudaimonic well-being. Scholars have studied goals and meaning separately, but research is sparse on the alignment of goals and meaning, especially in specific life domains and how ... -
Synthesis and antitubercular activity of triazole-linked 1,4-benzoquinone derivatives
(North-West University (South-Africa). Potchefstroom Campus, 2019-05)Tuberculosis (TB) has scourged humankind for hundreds of years. Not only are millions of people infected and killed by this disease annually, but more than a quarter of the world’s population is living with latent TB. ... -
Synthesis, cytotoxicity and antiplasmodial activity of novel ferrocenyl-artemisinin hybrids
(North-West University (South-Africa). Potchefstroom Campus, 2019)Malaria is caused by a parasite of the genus Plasmodium. Of the five species that infect humans, Plasmodium falciparum is the most dangerous. This disease caused 435 thousand deaths in 2017. It is estimated that 266 thousand ... -
Left ventricular structure and function and the link with oxidative stress in young adults : The African-PREDICT study
(North-West University (South-Africa). Potchefstroom Campus, 2019)In developed counties, the contribution of cardiovascular diseases (CVDs) to morbidity and mortality rates is well documented. In a study conducted in South Africa (N=4506), it was found that 92% of the study population ... -
Transdermal delivery of selected statins formulated in apricot kernel oil emulsions
(North-West University (South-Africa). Potchefstroom Campus, 2019)Statins are the leading active pharmaceutical ingredient (API) in the oral treatment of elevated cholesterol levels in the bloodstream. Oral administered statins claim to have gastro-intestinal side-effects, which could ... -
Serum selenium levels, the selenoprotein glutathione peroxidase and cardiovascular function in black South Africans
(North-West University (South-Africa). Potchefstroom Campus, 2019)In especially black South Africans non-communicable diseases such as hypertension and cardiovascular disease (CVD) have become an increasing burden with increased morbidity and mortality. Currently South Africa is undergoing ...
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