Health Sciences
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Interpretation of maximum absorbance data obtained from turbidimetry in plasma samples with varying fibrinogen concentration
(North-West University (South-Africa). Potchefstroom Campus, 2019-05)Cardiovascular disease (CVD) has become South Africa’s second largest cause of death. CVD is often associated with vascular injury, which initiates the coagulation cascade and formation of an occlusive or non-occlusive ... -
Research methods for conducting pharmacoepidemiological studies using medicines claims data
(North-West University (South-Africa). Potchefstroom Campus, 2019-05)This study aimed to evaluate the appropriate use of various research methods in pharmacoepidemiological studies using a South African medicines claims database. A literature review was carried out to conceptualise ... -
Concordance of goals and meaning in the intrapersonal life domain: Associations with demographic variables and well-being
(North-West University (South-Africa). Potchefstroom Campus, 2019-05)Goals and meaning are important facets of eudaimonic well-being. Scholars have studied goals and meaning separately, but research is sparse on the alignment of goals and meaning, especially in specific life domains and how ... -
Synthesis and antitubercular activity of triazole-linked 1,4-benzoquinone derivatives
(North-West University (South-Africa). Potchefstroom Campus, 2019-05)Tuberculosis (TB) has scourged humankind for hundreds of years. Not only are millions of people infected and killed by this disease annually, but more than a quarter of the world’s population is living with latent TB. ... -
Synthesis, cytotoxicity and antiplasmodial activity of novel ferrocenyl-artemisinin hybrids
(North-West University (South-Africa). Potchefstroom Campus, 2019)Malaria is caused by a parasite of the genus Plasmodium. Of the five species that infect humans, Plasmodium falciparum is the most dangerous. This disease caused 435 thousand deaths in 2017. It is estimated that 266 thousand ... -
Left ventricular structure and function and the link with oxidative stress in young adults : The African-PREDICT study
(North-West University (South-Africa). Potchefstroom Campus, 2019)In developed counties, the contribution of cardiovascular diseases (CVDs) to morbidity and mortality rates is well documented. In a study conducted in South Africa (N=4506), it was found that 92% of the study population ... -
Transdermal delivery of selected statins formulated in apricot kernel oil emulsions
(North-West University (South-Africa). Potchefstroom Campus, 2019)Statins are the leading active pharmaceutical ingredient (API) in the oral treatment of elevated cholesterol levels in the bloodstream. Oral administered statins claim to have gastro-intestinal side-effects, which could ... -
Serum selenium levels, the selenoprotein glutathione peroxidase and cardiovascular function in black South Africans
(North-West University (South-Africa). Potchefstroom Campus, 2019)In especially black South Africans non-communicable diseases such as hypertension and cardiovascular disease (CVD) have become an increasing burden with increased morbidity and mortality. Currently South Africa is undergoing ... -
Physico-chemical properties and intestinal epithelial permeation of baclofen solid-state forms
(North-West University (South-Africa). Potchefstroom Campus, 2019)Baclofen is a centrally acting muscle relaxant that acts as an agonist of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). It is primarily used to treat muscle spasticity in patients with multiple sclerosis ... -
An investigation of plant derived compounds as inhibitors of monoamine oxidase
(North-West University (South-Africa). Potchefstroom Campus, 2019)Computational chemistry, among other things, elucidates possible drug-molecular target interactions when an algorithm is run on a molecular modelling program. Although it is just a projection of reality, it enables researchers ... -
In vitro evaluation of the efficacy of selected medicinal plant extracts against multidrug resistant cancer cells
(North-West University (South-Africa). Potchefstroom Campus, 2019)Cancer is ranked as one of the leading causes of death globally, and a significant number of these diagnosed malignancies are found in lung tissue. Small cell lung cancer (SCLC) is a high grade neuroendocrine cancer, which ... -
Two-year longitudinal changes in body composition, physical activity and TV watching in relation to selected metabolic risk factors : the PAHL study
(North-West University (South-Africa). Potchefstroom Campus, 2019)Childhood obesity and physical inactivity (PI) are serious public health concerns of the twenty-first century. Increased prevalence of obesity and PI contribute to the high morbidity and mortality rates across the globe ... -
The use of apricot oil emulsions for the transdermal delivery of selected statins
(North-West University (South-Africa). Potchefstroom Campus, 2019)Familial hypercholesterolemia can be described as a condition associated with significantly high levels of low-density lipoprotein (LDL) in the plasma, caused by an autosomal-dominant genetic disorder of lipid metabolism. ... -
Synthesis and antimycobacterial activity of ciprofloxacin-triazole hybrids
(North-West University (South-Africa). Potchefstroom Campus, 2019)Tuberculosis (TB) is a public health crisis – infecting a quarter of the world’s population, also, inflicting 10.4 million morbidities and 1.7 mortalities in 2016. TB is effortlessly acquired through the inhalation of ... -
The relationship of pulse pressure and pulse pressure amplification with the reninangiotensin- aldosterone system in young adults : the African-PREDICT study
(North-West University (South-Africa). Potchefstroom Campus, 2019)Motivation: There are number of factors that are known to contribute to the elevation of blood pressure (BP) and the subsequent increase in cardiovascular risk. One of the most prominent systems is the renin-angiotensi ... -
Physical activity, body composition and handgrip strength among South African adults : the PURE study
(North-West University (South-Africa). Potchefstroom Campus, 2019)There is a consistent and progressive trend concerning a decrease in handgrip strength and physical activity with increased age that have significant implications for public health. It has been revealed that poor muscle ... -
Effect of omega-3 fatty acid supplementation on inflammation, muscle damage and exercise performance in athletes : a systematic review and meta-analysis
(North-West University (South-Africa). Potchefstroom Campus, 2019)Background: Large volumes of unaccustomed, intense exercise in athletes cause increased muscle damage, inflammation and suppression of the immune system resulting in delayed exercise recovery, overtraining syndrome, and ... -
Evaluation of the efficacy of selected anticancer compounds in multidrug resistant cell culture models
(North-West University (South-Africa). Potchefstroom Campus, 2019)Small cell lung cancer (SCLC) has an aggressive disseminating nature and the relapse of cancer patients after initial treatment is common. Acquired multidrug resistance (MDR) can often be attributed to over-expression of ... -
Long-lasting bio-behavioural effects of early-life sildenafil administration in stress-sensitive versus healthy control rats
(North-West University (South-Africa). Potchefstroom Campus, 2019)Major depressive disorder (MDD) in children and adolescents is prevalent, serious and of great concern globally. Yet, only two selective serotonin reuptake inhibitors (SSRIs) are approved for the treatment of juvenile MDD, ... -
Triazole-linked 1,4-naphthoquinone derivatives : synthesis and antiplasmodial activity
(North-West University (South-Africa). Potchefstroom Campus, 2019)Malaria is a protozoan disease transmitted to humans through female Anopheles mosquitoes. The malaria parasite thrives in tropical areas, thus people there are at higher risk, especially in third-world countries like ...
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