Health Sciences
Recent Submissions
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Biological evaluation of Pheroid® formulated plant bio-actives against oestrogen active breast cancer
(North-West University (South-Africa), 2022)Cancer is a serious public health complication worldwide. Annually 115 000 South Africans are diagnosed with cancer, where men have a lifetime risk of 1:7 and women a lifetime risk of 1:8. The most frequently diagnosed and ... -
Comparative evaluation of molecular-based detection methods for drug resistant tuberculosis
(North-West University (South-Africa), 2022)Tuberculosis (TB) is a globally problematic infectious disease and is currently one of the leading causes of death from any infectious disease worldwide. Mycobacterium tuberculosis (MTB) is notorious for developing ... -
Method development and validation for the analysis of medicinal cannabis products, aimed at developing a safety profile for South Africa
(North-West University (South-Africa), 2022)In the last few years, there has been an increase in the use of cannabis-based products for medicinal purposes. The preparation procedure, however, has not been standardised but is decided by the individual groups of ... -
The influence of buffer composition on the solubility of baclofen and sulfadoxine
(North-West University (South-Africa), 2022)The drug discovery process has developed immensely during the last couple of decades. The Biopharmaceutical Classification System (BCS) is a drug development tool that is based on correlation of solubility and membrane ... -
The relationship between health-specific self-efficacy and five-year change in blood pressure in young adults
(North-West University (South-Africa), 2022)Hypertension, defined as a persistently elevated blood pressure of 140/90 mmHg (Raymond & Couch, 2017), is one of the leading causes of secondary disease and premature death. This study is a sub-study of the longitudinal ... -
A pharmacological investigation of behavioural flexibility in zebrafish (Danio rerio)
(North-West University (South-Africa), 2022)Human and animal behaviour is ultimately directed at acquiring certain outcomes or achieving certain goals, or alternatively avoiding or mitigating negative outcomes. An intricate interplay between two components of ... -
Exploring quadruple stress in zebrafish (Danio rerio) as a novel model of posttraumatic stress disorder
(North-West University (South-Africa), 2022)Posttraumatic stress disorder (PTSD)1 is a severe and incapacitating mental disorder that manifests in some individuals following a personal encounter with or experiencing a perceived threat and/or witnessing/observing ... -
An investigation into the potential neurobiological constructs and long-term biobehavioural effects of perinatal combined antiretroviral therapy (cART)-exposure in the deer mouse
(North-West University (South-Africa), 2022)South Africa has one of the largest combination antiretroviral treatment (cART1) programs in the world with an estimated 7.52 million individuals that were living with human immunodeficiency virus (HIV2) by the end of 2018. ... -
Exploring role strain in caregivers of children living with disabilities in Lobatse, Botswana
(North-West University (South-Africa), 2022)Individuals living with disabilities demand the assistance of their loved ones, as they perform an indispensable role of informal caregiving to support them in performing their activities of daily living, something that ... -
Evaluation of the in vitro biocompatibility of cortical bone matrix
(North-West University (South-Africa), 2022)Bone grafts play a critical role in the medical field, providing people the opportunity to recover from high impact trauma that caused serious complex fractures. Bone tissue engineering is a field that gained great interest ... -
The facilitation of character strengths during early adulthood through Adventure Therapy : a critical review
(North-West University (South-Africa), 2022)Emerging adults are faced with a variety of challenges, including being constantly exposed to risk factors. Research, however, states that character strengths are significant enough to develop in their own right because ... -
Mental health challenges among the Lesbian, Gay, Bisexual,Transgender and Intersex community in Gaborone, Botswana
(North-West University (South-Africa), 2022)Studies worldwide have highlighted that there is high prevalence of depression, anxiety, suicide and substance use among Lesbian, Gays, Bisexual, Transgender and intersex (LGBTI+) community. Very few studies have been ... -
Guidelines for social work services in high risk schools in the Gauteng Province
(North-West University (South-Africa), 2022)This research seeks to address the social challenges children experience and the shortage of school social workers, by placing social workers from the Gauteng Department of Social Development (GDSD) in high risk (poorly ... -
Tryptophan metabolism in the deer mouse and its response to serotonergic intervention
(North-West University (South-Africa), 2022)Obsessive-compulsive disorder (OCD)1 is a debilitating neuropsychiatric condition that notably infringes on an individual’s quality of life. The condition is characterised by two primary symptoms, namely obsessions (intrusive ... -
A comparison of illuminance values obtained from three illuminance measuring instruments
(North-West University (South-Africa), 2022)In the field of occupational hygiene, light and the use of different lighting types have become fundamental control measures in reducing risks to health and safety while at the same time promoting increased productivity ... -
The extent and nature of food marketing to children in South African supermarkets
(North-West University (South-Africa), 2022)Background: Childhood overweight and obesity is on the rise in South Africa. If no obesity prevention strategies are implemented, South Africa could experience an overwhelming burden of obesity-related morbidities. Research ... -
Guidelines for conducting a rapid review in psychology research : a literature review
(North-West University (South-Africa), 2022)Rapid reviews are exponentially growing to inform policymakers, healthcare systems, and healthcare workers, as this review type informs all stakeholders within short time frames. In addition, it is noted that rapid reviews ... -
The in/appropriate application of attachment theory by mental health professionals in custody cases : a systematic review of literature
(North-West University (South-Africa), 2022)In the context of custody cases, attachment theory is often applied. This qualitative systematic review explores the way attachment theory inappropriately or appropriately applied by mental health professionals in this ... -
In silico screening, synthesis and in vitro determination of the biological activities of D-amino acid oxidase inhibitors
(North-West University (South-Africa), 2022)Schizophrenia is a mental disorder with many clinical and therapeutic challenges. Current therapy is based on outdated pathological theories while most antipschycotic drugs have a significant side effect profile. New ... -
Synthesis and in vitro antileishmanial efficacy of novel O-substituted derivatives of Nifuroxazide
(North-West University (South-Africa), 2022)Leishmaniasis is a neglected tropical disease (NTD) caused by the Leishmania parasite and this devastating vector-borne disease affects millions of people worldwide. There are up to 1 million new infections reportedly ...
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