Faculty of Health Sciences: Recent submissions
Now showing items 821-840 of 2404
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Trait forgiveness and dyadic adjustment predict postnatal depression
(Springer, 2018)The birth of a first child can be stressful on intimate partner relationships and the women having their first child. Conflict can occur, and hurts might be experienced, which could lead to post-partum depression. Thus, ... -
Sensitivity of fatty acid desaturation and elongation to plasma zinc concentration: a randomised controlled trial in Beninese children
(Cambridge Univ Press, 2018)Zn status may affect fatty acid (FA) metabolism because it acts as a cofactor in FA desaturase and elongase enzymes. Zn supplementation affects the FA desaturases of Zn-deficient rats, but whether this occurs in humans ... -
QTc prolongation, increased NT-proBNP and pre-clinical myocardial wall remodeling in excessive alcohol consumers: the SABPA study
(Elsevier, 2018)Alcohol contributes greatly to vascular and structural modifications. Due to differences in the metabolism and tolerance of alcohol between ethnic groups, the manner of these modifications may differ. We investigated the ... -
Development and validation of the simultaneous determination of artemisone, clofazimine and decoquinate with HPLC
(Avoxa, 2018)The aim of this study was to develop and validate a novel HPLC method for the simultaneous analysis of artemisone, clofazimine and decoquinate. Detection was obtained at two wavelengths; 284 nm (clofazimine) and 210 nm ... -
The evaluation of endpoint variability and implications for study statistical power and sample size in conscious instrumented dogs
(Elsevier, 2018)Introduction The sensitivity of a given test to detect a treatment-induced effect in a variable of interest is intrinsically related to the variability of that variable observed without treatment and the number of ... -
Psychosocial stress but not hypertensive status associated with angiogenesis in Africans
(Taylor & Francis, 2014)Aim. Increased angiogenic factors [vascular endothelial growth factor-A (VEGF-A) and angiopoietin-2 (Ang-2)] have been associated with vascular dysfunction and hypertension. Black Africans undergoing rapid urbanization ... -
Blunted neuro-endocrine responses linking depressive symptoms and ECG left ventricular hypertrophy in black Africans: the SABPA study
(Wolters Kluwer, 2014)Objective: Chronic psychosocial stress as experienced in an urban environment plays an important role in the aetiology of depression-related cardiovascular risk. It is uncertain whether acute mental stress responses aggravate ... -
Development of multiple-unit pellet system tablets by employing the SeDeM expert diagram system. II. Pellets containing different active pharmaceutical ingredients
(Taylor & Francis, 2019)The SeDeM Expert Diagram System (SeDeM EDS) was originally developed to provide information about the suitability of powders to produce direct compressible tablets. Multiple-unit pellet systems (MUPS) are dosage forms ... -
Development of multiple-unit pellet system tablets by employing the SeDeM expert diagram system. I. Pellets with different sizes
(Taylor & Francis, 2017)Multiple-unit pellet systems (MUPS) provide several pharmacokinetic and pharmacodynamic advantages over single-unit dosage forms, however, compression of pellets into MUPS tablets present certain challenges. Although the ... -
Type of dietary fat intakes in relation to all-cause and cause-specific mortality in US adults: an iso-energetic substitution analysis from the American National Health and Nutrition Examination Survey linked to the US mortality registry
(Cambridge Univ Press, 2018)Accumulating evidence indicates that saturated fat intake is related to mortality risk increase, whereas unsaturated fat intake is associated with reduced mortality risk. The aim of the present study was to estimate the ... -
Maybe it is not a goal that matters: a report from a physical activity intervention in youth
(Edizioni Minerva Medica, 2018)BACKGROUND: Decline in physical activity (PA), specifically in adolescents raises concerns. Setting goals and strategies are often used to increase the level of moderate-to-vigorous physical activity (MVPA), recently ... -
Phenolic and physicochemical stability of a functional beverage powder mixture during storage: effect of the microencapsulant inulin and food ingredients
(Wiley, 2018)BACKGROUND The need for a convenience herbal iced tea product with reduced kilojoules merited investigation of the shelf-life of powder mixtures containing a green Cyclopia subternata Vogel (honeybush) extract with proven ... -
Consumer knowledge and use of food and nutrition labelling in South Africa: a cross-sectional descriptive study
(Wiley, 2018)The noncommunicable disease burden can be addressed through population-wide interventions, including the promotion of healthy diets through the provision of adequate nutrition information on food labels. The study aimed ... -
Excipient-drug pharmacokinetic interactions: effect of disintegrants on efflux across excised pig intestinal tissues
(Elsevier, 2018)Pharmaceutical excipients were designed originally to be pharmacologically inert. However, certain excipients were found to have altering effects on drug pharmacodynamics and/or pharmacokinetics. Pharmacokinetic interactions ... -
Recent advances in three-dimensional cell culturing to assess liver function and dysfunction: from a drug biotransformation and toxicity perspective
(Taylor & Francis, 2018)The liver is a vital organ fulfilling a central role in over 500 major metabolic functions, including serving as the most essential site for drug biotransformation. Dysfunction of the drug biotransformation processes may ... -
In vitro activity of a new artemisinin derivative against Helicobacter pylori and its effect on biofilm formation
(Wiley, 2017)Artemisinin and its derivatives are widely used as antimalarial drugs, and are also active against extracellular and intracellular Helicobacter pylori. Here we investigated the in vitro activity of the new artemisinin ... -
Perinatal insults and neurodevelopmental disorders may impact age of diagnosis of Huntington’s disease
(Springer, 2018)Objectives: To determine whether early-life factors, like perinatal insults or neurodevelopmental disorders, are associated with the age of diagnosis of Huntington’s disease (HD). Methods: We used data from 13,863 ... -
Retrospective clinical analysis of adverse drug reactions associated with antiretroviral therapy in Tlokwe district, South Africa
(Taylor & Francis, 2018)Background: South Africa has the highest number of patients on antiretroviral therapy (ART) globally. Various obstacles were identified that influence effective reporting of adverse drug reactions (ADRs) in resource-limited ... -
Beauty and the body of the beholder: raters’ BMI has only limited association with ratings of attractiveness of the opposite sex
(Wiley, 2018)Objective Assortative mating for adiposity increases the genetic burden on offspring, but its causes remain unclear. One hypothesis is that people who have high adiposity find other people with obesity more physically ... -
Studies into the anxiolytic actions of agomelatine in social isolation reared rats: role of corticosterone and sex
(Sage, 2018)Anxiety disorders are severely disabling, while current pharmacological treatments are complicated by delayed onset, low remission rates and side-effects. Sex is also noted to contribute towards illness severity and treatment ...
