Faculty of Health Sciences: Recent submissions
Now showing items 801-820 of 2404
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Drug use among youth and adults in a population-based survey in South Africa
(AOSIS, 2018)Objective: Illicit drug use is a growing public health problem. The aim of the study was to assess the prevalence of drug use and the sociodemographic and health characteristics that influence it among young and adult South ... -
Diabetes in South African older adults: prevalence and impact on quality of life and functional disability – as assessed using SAGE Wave 1 data
(Taylor & Francis, 2018)Background: Diabetes is a chronic disease with severe late complications. It is known to impact the quality of life and cause disability, which may affect an individual’s capacity to manage and maintain longer-term health ... -
An international study on the feasibility of a standardized combined plasma clot turbidity and lysis assay: communication from the SSC of the ISTH
(Wiley, 2018)Abnormal fibrin clot structure, in particular increased fibrin fiber density and stiffness and resistance to fibrinolysis, are reported to be linked to cardiovascular disease (CVD) and a higher incidence of venous and ... -
An investigation of the monoamine oxidase inhibition properties of pyrrolo[3,4‐f]indole‐5,7‐dione and indole‐5,6‐dicarbonitrile derivatives
(Wiley, 2018)In recent studies, we have shown that pyrrolo[3,4‐f]indole‐5,7‐dione and indole‐5,6‐dicarbonitrile derivatives act as good potency in vitro inhibitors of the monoamine oxidase (MAO) enzymes. To expand on these series and ... -
The competitive intelligence process in sport: data collection properties of high-level cricket coaches
(Taylor & Francis, 2018)The aim of this study was to identify the data collection properties of cricket coaches, using the first stage of the 4Cs Competitive Intelligence (CI) process model of Weiss as framework. Semi-structured interviews were ... -
Heart rate variability and recovery as predictors of elite, African, male badminton players’ performance levels
(Taylor & Francis, 2018)The aim of this study was to determine whether pre-match, in-match, resting and post-match heart rate variability (HRV) as well as resting and post-match heart rate recovery (HRR) can serve as significant predictors of ... -
Evaluation and optimization of synthetic routes from dihydroartemisinin to the alkylamino-artemisinins artemiside and artemisone: a test of N-glycosylation methodologies on a lipophilic peroxide
(Elsevier, 2018)10-Alkylamino-artemisinins including artemiside and artemisone display enhanced activities against malaria. Earlier, dihydroartemisinin (DHA) TMS ether was converted by trimethylsilyl bromide into the 10-β-bromide that ... -
Topical delivery of selected growth factors
(Wiley, 2010)Growth factors can benefit from controlled release admin- istration technologies (i.e. topical or transdermal delivery). When compared with other epithelial membranes, the skin has less enzymatic activity and so provides ... -
Safety pharmacology in and for Africa: establishment of the pre-clinical drug development platform
(Elsevier, 2018)Southern Africa (South Africa as well as neighboring countries) has not had an infrastructure for testing the safety of new drugs or other therapeutic entities, including plant-based or herbal treatments coming from the ... -
Functionalization of PLGA nanoparticles with 1,3-β-glucan enhances the intracellular pharmacokinetics of rifampicin in macrophages
(Springer, 2018)Purpose Mycobacterium tuberculosis which causes tuberculosis, is primarily resident within macrophages. 1,3-β-glucan has been proposed as a ligand to target drug loaded nanoparticles (NPs) to macrophages. In this study ... -
Distinct intrinsic functional brain network abnormalities in methamphetamine‐dependent patients with and without a history of psychosis
(Wiley, 2018)Chronic methamphetamine use is associated with executive functioning deficits that suggest dysfunctional cognitive control networks (CCNs) in the brain. Likewise, abnormal connectivity between intrinsic CCNs and default ... -
A retrospective analysis of nickel exposure data at a South African base metal refinery
(Taylor & Francis, 2018)This study aimed to analyze historical soluble nickel exposure data from a South African base metal refinery and to identify trends in the soluble nickel exposure from 1981 until 2014 in the electrowinning department. Exposure ... -
Toward a comprehensive, theoretical model of compassion fatigue: an integrative literature review
(Wiley, 2018)This study was an integrative literature review in relation to compassion fatigue models, appraising these models, and developing a comprehensive theoretical model of compassion fatigue. A systematic search on PubMed, ... -
Leptin and its relation to autonomic activity, endothelial cell activation and blood pressure in a young black and white population: the African-PREDICT study
(Thieme, 2018)An increasing prevalence of obesity-related hypertension is observed in the youth and may have severe consequences for future cardiovascular disease development. Previous studies portrayed leptin as a potential factor ... -
One after the other: a novel Bluetongue virus strain related to Toggenburg virus detected in the Piedmont region (North‐western Italy), extends the panel of novel atypical BTV strains
(Wiley, 2018)In this rapid communication, a novel atypical bluetongue virus (BTV) strain detected in goats in the Piedmont region (north-western Italy) is described. This strain, BTV-Z ITA2017, is most related in Seg-2/VP-2 (83.8% ... -
Effect of non‐surgical weight management on weight and glycaemic control in people with type 2 diabetes: a comparison of interventional and non‐interventional outcomes at 3 years
(Wiley, 2018)Aims To examine the long‐term effectiveness of lifestyle weight management interventions, recommended in clinical guidelines for patients with type 2 diabetes mellitus (T2DM) and obesity. Materials and methods Electronic ... -
Household access to traditional and indigenous foods positively associated with food security and dietary diversity in Botswana
(Cambridge Univ Press, 2018)Objective To determine access to traditional and indigenous foods (TIF) and the association with household food security, dietary diversity and women’s BMI in low socio-economic households. Design Sequential explanatory ... -
Antecedents of basic psychological need satisfaction of pharmacy students: the role of peers, family, lecturers and workload
(Elsevier, 2018)Background Self-determination theory (SDT) provides a model to improve pharmacy students' well-being or functioning in their study context. According to SDT, students need a context that satisfies their needs for autonomy, ... -
Thiobarbituric acid-reactive substances relate to arterial stiffness and blood pressure in 6 to 8-year-old boys stratified by maternal risk
(Nature, 2018)Early cardiovascular disease (CVD) onset can be inflicted by familial cardiovascular and lifestyle risk factors. We aimed to compare phenotypic characteristics and explore associations between oxidative stress and vascular ... -
Deriving an optimal threshold of waist circumference for detecting cardiometabolic risk in sub-Saharan Africa
(Nature, 2018)BACKGROUND: Waist circumference (WC) thresholds derived from western populations continue to be used in sub-Saharan Africa (SSA) despite increasing evidence of ethnic variation in the association between adiposity and ...
