Faculty of Health Sciences: Recent submissions
Now showing items 1221-1240 of 2404
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A novel RP-HPLC method for the detection and quantification of clarithromycin or spiramycin in bulk drug samples and dosage forms
(Innovare Academic Sciences, 2016)Objective: This study was aimed at developing an HPLC method that would be suitable and sufficiently robust to analyze clarithromycin or spiramycin from bulk materials, amorphous solid dispersions as well as when included ... -
Role of novel drug delivery systems in bioavailability enhancement: at a glance
(DYR Labs, 2016)Novel drug delivery systems (NDDS) are one of the most strategies which enable to overcome the problems related to drug bioavailability. It is the rate and extent to which a drug becomes available to the target tissue after ... -
Vortioxetine promotes early changes in dendritic morphology compared to fluoxetine in rat hippocampus
(Elsevier, 2016)Preclinical studies reveal that the multimodal antidepressant vortioxetine enhances long-term potentiation and dendritic branching compared to a selective serotonin reuptake inhibitor (SSRI). In the present study, we ... -
Repurposing of antiparasitic drugs: the hydroxy-naphthoquinone buparvaquone inhibits vertical transmission in the pregnant neosporosis mouse model
(BioMed Central, 2016)The three anti-malarial drugs artemiside, artemisone, and mefloquine, and the naphthoquinone buparvaquone known to be active against theileriosis in cattle and Leishmania infections in rodents, were assessed for activity ... -
Complexation studies of 177Lu with ethylenediaminetetramethylene phosphonic acid (EDTMP) as a bone pain palliative therapeutic radiopharmaceutical
(Elsevier, 2016)Therapeutic radiopharmaceuticals for bone pain palliation play an important role in providing quality of life for cancer patients with metastatic bone cancer. There is currently interest in using 177Lu in many radiopharm ... -
Cell based assays for anti-Plasmodium activity evaluation
(Elsevier, 2016)Malaria remains one of the most common and deadly infectious diseases worldwide. The severity of this global public health challenge is reflected by the approximately 198 million people, who were reportedly infected in ... -
Sinigrin and Its therapeutic benefits
(MDPI, 2016)Sinigrin (allyl-glucosinolate or 2-propenyl-glucosinolate) is a natural aliphatic glucosinolate present in plants of the Brassicaceae family, such as broccoli and brussels sprouts, and the seeds of Brassica nigra (mustard ... -
Synthesis and biological evaluation of pentacycloundecylamines and triquinylamines as voltage-gated calcium channel blockers
(Wiley, 2016)Preclinical studies for neurodegenerative diseases have shown a multi-targeted approach to be successful in the treatment of these complex disorders with several pathoetiological pathways. Polycyclic compounds, such as ... -
Probiotic treatment reduces depressive-like behaviour in rats independently of diet
(Elsevier, 2017)The gut microbiota has recently emerged as an important regulator of brain physiology and behaviour in animals, and ingestion of certain bacteria (probiotics) therefore appear to be a potential treatment for major depressive ... -
Prevalence of chronic diseases in private healthcare sector of South Africa: a threat to public health
(AJOL, 2016)Purpose: To evaluate the prevalence of patients suffering from registered chronic disease list (CDL) conditions in a section of the South African private health sector from 2008 - 2012. Methods: This study was a retrospective ... -
Carbon-14 radiolabelling and tissue distribution evaluation of a potential anti-TB compound
(Wiley, 2016)This paper describes a five-step synthesis of a carbon-14-labelled pyrazole compound (11). A total of 2.96 MBq of 11 was obtained with the specific activity of 2242.4 MBq/mmol. The radiochemical purity was >99%, and the ... -
In vitro activity of artemisone and artemisinin derivatives against extracellular and intracellular Helicobacter pylori
(Elsevier, 2016)The in vitro activity of the new artemisinin derivative artemisone as well as other molecules of the same class against Helicobacter pylori and their effects when combined with standard antibiotics were evaluated. Since ... -
Successful implantation of an abdominal aortic blood pressure transducer and radio-telemetry transmitter in guinea pigs: anaesthesia, analgesic management and surgical methods, and their influence on hemodynamic parameters and body temperature
(Elsevier, 2016)Introduction Guinea pigs (GPs) are a valuable cardiovascular pharmacology model. Implantation of a radio-telemetry system into GPs is, however, challenging and has been associated with a high failure rate in the past. We ... -
Anti-epileptic prescribing patterns in the South African private health sector (2008-2013)
(Taylor & Francis, 2016)Background: Little is known about longitudinal prescribing practices for anti-epileptic drugs (AEDs) in South Africa. The prescribing patterns and associated direct medicine costs of AEDs in the private ... -
Mind your state: insights into antidepressant nonadherence
(MedPharm Publications, 2016)Major depressive disorder (MDD) is an insidious disease and affects up to 15% of the global population. Although MDD responds to a wide range of pharmacological treatment options, a number of factors, i.e. not adhering ... -
Straightforward conversion of decoquinate into inexpensive tractable new derivatives with significant antimalarial activities
(Elsevier, 2016)As part of a programme aimed at identifying rational new triple drug combinations for treatment of malaria, tuberculosis and toxoplasmosis, we have selected quinolones as one component, given that selected examples exhibit ... -
Differential interaction with the serotonin system by S-ketamine, vortioxetine, and fluoxetine in a genetic rat model of depression
(Springer, 2016)Rationale The mechanisms mediating ketamine’s antidepressant effect have only been partly resolved. Recent preclinical reports implicate serotonin (5-hydroxytryptamine; 5-HT) in the antidepressant-like action of ketamine. ... -
Methylene homologues of artemisone: an unexpected structure-activity relationship and a possible implication for the design of C10-substituted artemisinins
(Wiley, 2016)We sought to establish if methylene homologues of artemisone are biologically more active and more stable than artemisone. The analogy is drawn with the conversion of natural O- and N-glycosides into more stable C-glycosides ... -
Prescribing patterns of non-steroidal anti-inflammatory drugs in chronic kidney disease patients in the South African private sector
(Springer, 2016)Background Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used pharmaceutical agents worldwide. NSAIDs are considered nephrotoxic and should therefore be used with caution or be avoided completely ... -
Developing soft skills (also known as pervasive skills): usefulness of an educational game
(Emerald, 2016)Purpose – The purpose of this paper is to evaluate the usefulness of an educational game to develop soft skills (also known as pervasive skills), from the perspectives of three groups of role-players (student participants, ...
