Faculty of Health Sciences: Recent submissions
Now showing items 1201-1220 of 2404
-
Synthesis and in vitro biological activities of ferrocenyl-chalcone amides
(Springer, 2016)A series of aminoferrocenyl–chalcone amides 11–19 were synthesized through condensation of a carboxylic acid-functionalized chalcone 10 with ferrocenylamines, using 1,1′-carbonyldiimidazole as the coupling agent. The ... -
Systematic evaluation of skeletal fractures caused by induction of electroconvulsive seizures in rat state a need for attention and refinement of the procedure
(Cambridge Univ Press, 2017)Electroconvulsive therapy (ECT) is one of the most efficient treatments for major depression. Electroconvulsive seizures (ECS), the animal model of ECT, is widely used to study both mechanisms of action and adverse effects ... -
The monoamine oxidase inhibition properties of selected structural analogues of methylene blue
(Elsevier, 2017)The thionine dye, methylene blue (MB), is a potent inhibitor of monoamine oxidase (MAO) A, a property that may, at least in part, mediate its antidepressant effects in humans and animals. The central inhibition of MAO-A ... -
Lipid-based nutrient supplements and linear growth in children under 2 years: a review
(Cambridge University Press, 2017)The prevalence of stunting remains high in low- and middle-income countries despite adoption of comprehensive nutrition interventions, particularly in low-income countries. In the present paper, we review current evidence ... -
Exploring resilience in nurses caring for older persons
(Elsevier, 2017)Background A shortage of nurses caring for older persons is experienced due to adverse working conditions. Resilience might empower nurses to persevere while caring for older persons. Research regarding the resilience of ... -
Promoting food security through indigenous and traditional food crops
(Taylor & Francis, 2016)Despite many factors weighing in South Africa’s favor on the agricultural front, including having official “food secure” status, millions of households have insufficient access to nutritionally safe food. This is largely ... -
Evaluation of P-glycoprotein modulation by pharmaceutical excipients
(SAPJ, 2017)Modulation of P-glycoprotein (P-gp) may play a significant role in the systemic delivery of poorly bioavailable drugs e.g. anti-neoplastic drugs. Many compounds from different chemical classes, including pharmaceutical ... -
The relationship of nitric oxide synthesis capacity, oxidative stress, and albumin-to-creatinine ratio in black and white men: the SABPA study
(Springer, 2016)Inadequate substrate availability and increased nitric oxide synthase inhibitor levels attenuate nitric oxide (NO) synthesis, whereas increased vascular oxidative stress may lead to inactivation of NO. We compared markers ... -
Clinicians guide for cue-based transition to oral feeding in preterm infants: an easy-to-use clinical guide
(Wiley, 2017)RATIONALE, AIMS AND OBJECTIVES: This article aims to provide evidence to guide multidisciplinary clinical practitioners towards successful initiation and long-term maintenance of oral feeding in preterm infants, directed ... -
Internal and external match loads of university-level soccer players: a comparison between methods
(Lippincott, Williams & Wilkins, 2016)The aim of this study was to use individualized intensity zones to compare the external (velocity and Player Load, PL) and internal loads (heart rate, HR) of a cohort of university-level soccer players. Thirteen soccer ... -
Boys in middle childhood placed in a clinic school: experiences of sexual abuse.
(South African Society on the Abuse of Children (SAPSAC), 2014)This study formed part of a larger research project, which aimed to develop an intervention strategy to support sexually abused boys in their middle childhood placed in a clinic school. The experiences of these boys were ... -
A critical synthesis of interventions to reduce stigma attached to mental illness
(AOSIS, 2014)Background: Interventions have been developed and implemented to reduce the stigma attached to mental illness. However, mental healthcare users are still stigmatised. Objective: The objective of this study was to critically ... -
Repeated anaesthesia with isoflurane and medetomidine-midazolam-fentanyl in guinea pigs and its influence on physiological parameters
(PLoS, 2017)Repeated anaesthesia may be required in experimental protocols and in daily veterinary practice, but anaesthesia is known to alter physiological parameters in GPs (Cavia porcellus, GPs). This study investigated the effects ... -
MicroRNA 101b is downregulated in the prefrontal cortex of a genetic model of depression and targets the glutamate transporter SLC1A1 (EAAT3) in vitro
(Oxford Univ Press, 2016)Background: MicroRNAs (miRNAs) are small regulatory molecules that cause translational repression by base pairing with target mRNAs. Cumulative evidence suggests that changes in miRNA expression may in part underlie the ... -
Perceptions of pharmacists towards the importance of work-life balance: a descriptive cross-sectional study from Pakistan
(College of Pharmacists of Buenos Aires Province, Argentina, 2016)The present study was designed to evaluate the pharmacist’s perceptions towards the impor- tance of different factors responsible for work-life in Pakistan. A descriptive cross-sectional study design was used. A questionnaire ... -
Are community pharmacists and nutritionists capable for obesity management in Pakistan? A cross-sectional study
(Marmara University, Faculty of Pharmacy, 2016)The main objective of the study was to evaluate knowledge and perceptions among community pharmacists and nutritionists/ dietitians regarding obesity management in Pakistan. A semi-structured questionnaire was distributed ... -
Students’ perception of the perceived availability and diversion of methylphenidate in a South African tertiary academic institution
(SAPJ, 2016)Aims: To determine where residence students from a South African tertiary institution get methylphenidate for both appropriate and non-medical use, where they think they could get it and how easy they think it is to ... -
Inactivation of Anopheles gambiae Glutathione Transferase ε2 by Epiphyllocoumarin
(Hindawi Publishing Corporation, 2016)Glutathione transferases (GSTs) are part of a major family of detoxifying enzymes that can catalyze the reductive dehydrochlorination of dichlorodiphenyltrichloroethane (DDT). The delta and epsilon classes of insect GSTs ... -
Synthesis and biological evaluation of a series of non-hemiacetal ester derivatives of artemisinin
(Elsevier, 2016)In an attempt to improve the efficacy and stability of current, clinically used artemisinins, a series non-hemiacetal ester derivatives of artemisinin were synthesized and evaluated for their in vitro antiplasmodial and ... -
Differential expression of postsynaptic NMDA and AMPA receptor subunits in the hippocampus and prefrontal cortex of the flinders sensitive line rat model of depression
(Wiley, 2016)Glutamatergic abnormalities have recently been implicated in the pathophysiology of depression, and the ionotropic glutamate receptors in particular have been suggested as possible underlying molecular determinants. The ...
