Browsing by Subject "Mass spectrometry"
Now showing items 1-5 of 5
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A novel UPLC-MS/MS based method to determine the activity of N-acetylglutamate synthase in liver tissue
(Elsevier, 2016)Background N-acetylglutamate synthase (NAGS) plays a key role in the removal of ammonia via the urea cycle by catalyzing the synthesis of N-acetylglutamate (NAG), the obligatory cofactor in the carbamyl phosphate synthetase ... -
An analytical method to investigate the metabolites and co-factors of the methionine-homocysteine cycle in women using combined oral contraceptives and non-users
(North-West University (South Africa), 2022)Biotransformation protects the body from endogenous and exogenous substances like combined oral contraceptives (COCs). During biotransformation, estrogen undergoes methylation with the assistance of catechol-O-methyltransferase ... -
Development and validation of a single analytical method for the determination of tryptophan, and its kynurenine metabolites in rat plasma
(Elsevier, 2012)It is highly beneficial to monitor the activity of the kynurenine pathway in a large series of samples with high accuracy and reliability in a single experimental protocol. We have developed a rapid specific solid-phase ... -
From untargeted LC-QTOF analysis to characterisation of opines in abalone adductor muscle: theory meets practice
(Elsevier, 2017)Abalone have a unique ability to use pyruvate, various amino acids and dehydrogenases, to produce opines as means to prevent the accumulation of NADH during anaerobic conditions. In this study, the theoretical masses, ... -
Results, meta-analysis and a first evaluation of UNOxR, the urinary nitrate-to-nitrite molar ratio, as a measure of nitrite reabsorption in experimental and clinical settings
(Springer, 2018)We recently found that renal carbonic anhydrase (CA) is involved in the reabsorption of inorganic nitrite (NO2−), an abundant reservoir of nitric oxide (NO) in tissues and cells. Impaired NO synthesis in the endothelium ...
