Veranderinge van die plasmaproteïene, proteïengebonde-jodium en die lipogram tydens eksperimentele aterosklerose

Abstract

The object of this study was to determine what changes the plasma proteins and thyroid function exhibit during experimental generation of atherosclerosis in experimental animals and how this corresponded with the measurable changes of these phenomena during the natural development of this disease in man. Experimental animals were fed on a diet rich in fat and the plasma proteins were determined over periods of four months with the aid of electrophoresis (chapter 5). The protein bound iodine (P .B.I.) of the animals was also determined over periods of four months and compared (see chapter 5). Together with this the changes in the lipogram over the same periods were also correlated. From the experiments which were conducted, it was established that the albumin fraction of the plasma proteins showed a drop during the experimental generation of atheroschlerosis while the globulins (especially globulin) showed a rising tendency. In this experiment the P.B. I. showed a falling tendency which implies that the thyroid hormone synthesis mechanism was depressed. The blood pattern changes in a few experimental animals were compared with each other. It was apparent that there was a close relationship between lipaemia, an increase in the albumin fraction of the plasma proteins on the one hand and a decrease in thyroid function on the other. These changes were interpreted in terms of disturbances of the metabolic regulating mechanisms of the body. It was concluded that both these criteria could be useful in the early diagnosis of the development of atherosclerosis - also in man.