Euphorbias of South Africa: two new phorbol esters from Euphorbia bothae

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Date
2010Author
Popplewell, Wendy L.
Brand, Linda
Harvey, Brian Herbert
Marais, Eloise A.
Davies-Coleman, Michael T.
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Two known phorbol esters, 12-deoxyphorbol-13-isobutyrate-20-acetate (1) and 12-deoxyphorbol-13-(2-methylbutyrate)-20-acetate (2), and two new phorbol esters, 12-deoxyphorbol-13-isobutyrate-16-angelate-20-acetate (3) and 12-deoxyphorbol-13-(2-methylbutyrate)-16-angelate-20-acetate (4), were isolated from the endemic South African plant Euphorbia bothae. Standard spectroscopic techniques were used to elucidate the structures of all four compounds. The interaction of 1-4 with opioid receptors was explored in an attempt to explain the unexplained stupor occasionally observed in herbivores browsing on E. bothae
URI
http://hdl.handle.net/10394/5972http://hdl.handle.net/10520/EJC24500
http://journals.co.za/content/chem/63/1/EJC24500
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- Faculty of Health Sciences [2404]