Browsing Health Sciences by Subject "Malaria"
Now showing items 1-10 of 32
-
Artemisinin–quinoline hybrids : design, synthesis and antimalarial activity
(North-West University, 2013)Introduction - Malaria is a major global health problem, with more than 500 million reported cases and at least 1 million deaths each year. The main problem with malaria control is the emerging drug resistance. Plasmodium ... -
Development and evaluation of a self-emulsifying drug delivery system for artemether and lumefantrine
(North-West University (South-Africa), 2019)Malaria is a grave concern globally, however, in sub-Saharan Africa it remains an even more severe problem due to the fact that more than 90% of all malaria cases caused by Plasmodium falciparum reside in this region. The ... -
Development and evaluation of a solid oral dosage form for an artesunate and mefloquine drug combination
(2014)Malaria affects about forty percent of the world’s population. Annually more than 1.5 million fatalities due to malaria occur and parasite resistance to existing antimalarial drugs such as mefloquine has already reached ... -
Development and evaluation of an oral fixed–dose triple combination dosage form for artesunate, dapsone and proguanil
(North-West University, 2011)Malaria is a life–threatening disease caused by Plasmodium spp and causes over one million deaths annually. The complex life cycle of the malaria parasite offers several points of attack for the antimalarial drugs. The ... -
Development of lipid matrix tablets containing a double fixed dose combination of artemisone and lumefantrine
(North-West University, 2018)Malaria is one of the most important parasitic diseases as well as one of the most life-threatening diseases known to man. This vector-borne disease caused by Plasmodium spp., is responsible for over 438 000 deaths globally, ... -
Development of lipid matrix tablets containing a double-fixed dose combination of artemether and lumefantrine
(North-West University (South-Africa), 2019)Malaria remains one of the most serious vector-borne and prominent life-threatening diseases in sub-Saharan Africa. Africa has the heaviest malarial disease burden in the world, accounting for 91% of the estimated 445 000 ... -
Dihydroartemisinin esters as prodrugs against resistant P. falciparum strains
(North-West University, 2011)Malaria is caused by the Plasmodium sp. parasite that infects the red blood cells. Of the four types of malaria, the most serious type is transmitted by Plasmodium falciparum species. It can be life threatening. The other ... -
The discriminatory ability of analytical quality control test methods : a comparison of test results from different international monographs of quinine sulfate tablets
(2013)Malaria is a parasitic disease claiming one million lives worldwide annually. Unfortunately, malaria-endemic countries in need of good quality medicines are also overwhelmed with counterfeit or substandard medicine. This ... -
The effect of Pheroid® technology on the bioavailability of artemisone in primates
(2014)Malaria is one the world’s most devastating diseases. Several classes of drugs are used to treat malaria. Artemisinin combination therapy is the first line treatment of uncomplicated malaria. The artemisinin derivative, ... -
The effect of Pheroid™ technology on the bioavailability of quinoline–based anti–malarial compounds in primates
(North-West University, 2012)Resistance against anti-malarial drugs remains one of the greatest obstacles to the effective control of malaria. The current first-line treatment regimen for uncomplicated P.falciparum malaria is based on artemisinin ...
