dc.contributor.author | Malan, L. | |
dc.contributor.author | Baumgartner, J. | |
dc.contributor.author | Smuts, C.M. | |
dc.contributor.author | Calder, P. | |
dc.date.accessioned | 2017-05-15T07:21:22Z | |
dc.date.available | 2017-05-15T07:21:22Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Malan, L. et al. 2016. Low immune cell ARA and high plasma 12-HETE and 17-HDHA in iron-deficient South African school children with allergy. Prostaglandins leukotrienes and essential fatty acids (PLEFA), 110:35-41. [ http://dx.doi.org/10.1016/j.plefa.2016.05.006] | |
dc.identifier.issn | 0952-3278 | |
dc.identifier.issn | 1532-2823 (Online) | |
dc.identifier.uri | http://hdl.handle.net/10394/23032 | |
dc.identifier.uri | http://dx.doi.org/10.1016/j.plefa.2016.05.006 | |
dc.description.abstract | Allergy has been associated with altered fatty acid and inflammatory status. In this cross-sectional study of 321 rural iron deficient (ID) South African children (aged 6–11 years), a subsample (n=111) of children with parent-reported allergy data were divided into an allergic (n=30) and non-allergic (n=81) group and compared. PBMC arachidonic acid (ARA; P=0.010) and the PBMC ARA to dihomo-gamma-linolenic acid (DGLA) ratio (P=0.035) were lower in the allergic children. Plasma 12-hydroxyeicosatetraenoic acid and 17-hydroxydocosahexaenoic acid (17-HDHA) were higher (P=0.040 and 0.020, respectively) in the allergic group. Thus, a fatty acid composition and lipid mediator levels indicative of increased release of ARA from PBMC membranes, increased inflammation as well as the resolving thereof, were associated with parent-reported allergy symptoms. This study used baseline data of an intervention study which was registered at clinicaltrials.gov as NCT01092377 | |
dc.language.iso | en | |
dc.publisher | Elsevier | |
dc.subject | Allergy | |
dc.subject | Fatty acid composition | |
dc.subject | Arachidonic acid | |
dc.subject | Lipid mediatotor | |
dc.subject | Inflammation | |
dc.subject | Inflammation-resolving | |
dc.title | Low immune cell ARA and high plasma 12-HETE and 17-HDHA in iron-deficient South African school children with allergy | |
dc.type | Article | |
dc.contributor.researchID | 24054909 - Baumgartner, Jeannine | |
dc.contributor.researchID | 10091130 - Malan, Linda | |
dc.contributor.researchID | 20924445 - Smuts, Cornelius Mattheus | |