Low immune cell ARA and high plasma 12-HETE and 17-HDHA in iron-deficient South African school children with allergy
Loading...
Date
Authors
Malan, L.
Baumgartner, J.
Smuts, C.M.
Calder, P.
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Allergy has been associated with altered fatty acid and inflammatory status. In this cross-sectional study of 321 rural iron deficient (ID) South African children (aged 6–11 years), a subsample (n=111) of children with parent-reported allergy data were divided into an allergic (n=30) and non-allergic (n=81) group and compared. PBMC arachidonic acid (ARA; P=0.010) and the PBMC ARA to dihomo-gamma-linolenic acid (DGLA) ratio (P=0.035) were lower in the allergic children. Plasma 12-hydroxyeicosatetraenoic acid and 17-hydroxydocosahexaenoic acid (17-HDHA) were higher (P=0.040 and 0.020, respectively) in the allergic group. Thus, a fatty acid composition and lipid mediator levels indicative of increased release of ARA from PBMC membranes, increased inflammation as well as the resolving thereof, were associated with parent-reported allergy symptoms. This study used baseline data of an intervention study which was registered at clinicaltrials.gov as NCT01092377
Description
Citation
Malan, L. et al. 2016. Low immune cell ARA and high plasma 12-HETE and 17-HDHA in iron-deficient South African school children with allergy. Prostaglandins leukotrienes and essential fatty acids (PLEFA), 110:35-41. [ http://dx.doi.org/10.1016/j.plefa.2016.05.006]