Faculty of Health Sciences: Recent submissions
Now showing items 861-880 of 2404
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S-ketamine mediates its acute and sustained antidepressant-like activity through a 5-HT1B receptor dependent mechanism in a genetic rat model of depression
(Frontiers Media, 2018)Rationale: The mechanisms responsible for the unique antidepressant properties of ketamine have only been partly resolved. Recent preclinical reports implicate the neurotransmitter serotonin [5-hydroxytryptamine (5-HT)] ... -
Recent developments in our understanding of the implications of traditional African medicine on drug metabolism
(Taylor & Francis, 2018)Introduction: The use of traditional herbal medicines has become increasingly popular globally, but in some countries, it is the main or sometimes even the only healthcare service available in the most rural areas. This ... -
Benzopyrone represents a privilege scaffold to identify novel adenosine A1/A2A receptor antagonists
(Elsevier, 2018)Adenosine receptor antagonists are under investigation as potential drug candidates for the treatment of certain cancers, neurological disorders, depression and potentially improve tumour immunotherapy. The benzo-γ-pyrone ... -
European cardiovascular mortality over the last three decades: evaluation of time trends, forecasts for 2016
(Società Editrice Universo, 2017)Background. The circulatory diseases, in particular ischemic heart diseases and stroke, represent the main causes of death worldwide both in high income and in middle and low income countries. Our aim is to provide a ... -
Homeless in observatory, Cape Town through the lens of Max-Neef’s fundamental human needs taxonomy
(Univ Stellenbosch, 2017)The level of homelessness on the streets of South Africa is regarded as a slow-moving tragedy. The aim of this article is to explain the profile of the homeless in Observatory, Cape Town using Max-Neef’s Fundamental Human ... -
Exploring the play of middle childhood children in a poor community in the North West Province: caregivers’ experiences
(Univ Stellenbosch, 2017)Play is affected by the specific community and culture children live in. Through an explorative descriptive design this qualitative study explored the experiences of play of middle childhood children in a poor community ... -
Early vascular aging in the HIV infected: is arterial stiffness assessment the ideal tool?
(Taylor & Francis, 2017) -
Medication administration errors and related deviations from safe practice: an observational study
(Wiley, 2017)Aims and objectives To determine the incidence of medication administration errors, medication administration-related deviations from safe practice as well as factors associated with these errors in medical and surgical ... -
Targeting inflammation to reduce cardiovascular disease risk: a realistic clinical prospect?
(Wiley, 2017)Data from basic science experiments is overwhelmingly supportive of the causal role of immune-inflammatory response(s) at the core of atherosclerosis, and therefore, the theoretical potential to manipulate the inflammatory ... -
Evaluation of a mass-media campaign to increase the awareness of the need to reduce discretionary salt use in the South African population
(MDPI, 2017)The South African strategic plan to reduce cardiovascular disease (CVD) includes reducing population salt intake to less than 5 g/day. A mass media campaign was undertaken to increase public awareness of the association ... -
Homocysteine and nighttime blood pressure dipping - is there a connection?
(Oxford Univ Press, 2017) -
Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults
(Elsevier, 2017)Background Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health consequences throughout the life-course. Our aim was to estimate worldwide trends in mean body-mass index ... -
Clot structure and fibrinolysis in thrombosis and hemostasis (Editorial)
(Hindawi, 2017) -
Roadmap to achieve 25% hypertension control in Africa by 2025
(Clinics Cardive, 2017)Background and aim: The Pan-African Society of Cardiology (PASCAR) has identified hypertension as the highest area of priority for action to reduce heart disease and stroke on the continent. The aim of this PASCAR roadmap ... -
Trends in obesity and diabetes across Africa from 1980 to 2014: an analysis of pooled population-based studies
(Oxford Univ Press, 2017)Background The 2016 Dar Es Salaam Call to Action on Diabetes and Other non-communicable diseases (NCDs) advocates national multi-sectoral NCD strategies and action plans based on available data and information from countries ... -
Clarifying the factor structure of the mental health continuum short form in three languages: a bifactor exploratory structural equation modeling approach
(Sage, 2017)The Mental Health Continuum Short Form measures both the private and public aspects of overall positive mental health. This study explored the factor structure of English (n = 324), Afrikaans (n = 476), and Setswana (n = ... -
Agreement between specific measures of adiposity and associations with high blood pressure in black South African women
(Wiley, 2017)Objectives To derive percentage body fat (%BF) cut-points according to body mass index (BMI) categories for adult black South African women and to investigate the agreement between adiposity classifications according to ... -
The relation of blood pressure and carotid intima-media thickness with the glutathione cycle in a young bi-ethnic population: the African-PREDICT study
(Elsevier, 2017)Oxidative stress has been implicated in the development of hypertension, arterial stiffness and atherosclerosis. Optimal functioning of the enzymatic antioxidant system is central to prevent increased oxidative stress and ... -
Fruit, vegetable, and legume intake, and cardiovascular disease and deaths in 18 countries (PURE): a prospective cohort study
(Elsevier, 2017)Background The association between intake of fruits, vegetables, and legumes with cardiovascular disease and deaths has been investigated extensively in Europe, the USA, Japan, and China, but little or no data are available ... -
Medicines dispensers' knowledge on the implementation of an artemisinin-based combination therapy policy for the treatment of uncomplicated malaria in Tanzania
(Royal Pharmaceutical Society, 2017)Objectives In 2005, Tanzania changed its policy for uncomplicated malaria treatment from sulphadoxine–pyrimethamine (SP) to artemisinin-based combination therapy (ACT), specifically artemether–lumefantrine (ALU). SP remains ...
