dc.contributor.author | Beteck, Richard M. | |
dc.contributor.author | Smit, Frans J. | |
dc.contributor.author | Haynes, Richard K. | |
dc.contributor.author | N'Da, David D. | |
dc.date.accessioned | 2016-02-15T07:20:48Z | |
dc.date.available | 2016-02-15T07:20:48Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Beteck, R.M. et al. 2014. Recent progress in the development of anti-malarial quinolones. Malaria journal,13:339-348. [https://doi.org/10.1186/1475-2875-13-339] | en_US |
dc.identifier.issn | 1475-2875 (Online) | |
dc.identifier.uri | http://hdl.handle.net/10394/16290 | |
dc.identifier.uri | https://malariajournal.biomedcentral.com/articles/10.1186/1475-2875-13-339 | |
dc.identifier.uri | https://doi.org/10.1186/1475-2875-13-339 | |
dc.description.abstract | Available anti-malarial tools have over the ten-year period prior to 2012 dramatically reduced the number of fatalities
due to malaria from one million to less than six-hundred and thirty thousand. Although fewer people now die from
malaria, emerging resistance to the first-line anti-malarial drugs, namely artemisinins in combination with quinolines and
arylmethanols, necessitates the urgent development of new anti-malarial drugs to curb the disease. The quinolones are a
promising class of compounds, with some demonstrating potent in vitro activity against the malaria parasite. This review
summarizes the progress made in the development of potential anti-malarial quinolones since 2008. The efficacy of these
compounds against both asexual blood stages and other stages of the malaria parasite, the nature of putative targets,
and a comparison of these properties with anti-malarial drugs currently in clinical use, are discussed | en_US |
dc.description.sponsorship | North-West University;
South African Medical Research
Council (MRC) with funds from National Treasury under its Economic
Competitiveness and Support Package | en_US |
dc.language.iso | en | en_US |
dc.publisher | BioMed Central | en_US |
dc.subject | Endochin | en_US |
dc.subject | Quinolone | en_US |
dc.subject | Decoquinate | en_US |
dc.title | Recent progress in the development of anti-malarial quinolones | en_US |
dc.type | Article | en_US |
dc.contributor.researchID | 20926588 - Smit, Frans Johannes | |
dc.contributor.researchID | 22966390 - Haynes, Richard Kingston | |
dc.contributor.researchID | 20883072 - N'Da, David Dago | |
dc.contributor.researchID | 25159194 - Beteck, Richard Mbi | |