Recent progress in the development of anti-malarial quinolones
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BioMed Central
Abstract
Available anti-malarial tools have over the ten-year period prior to 2012 dramatically reduced the number of fatalities
due to malaria from one million to less than six-hundred and thirty thousand. Although fewer people now die from
malaria, emerging resistance to the first-line anti-malarial drugs, namely artemisinins in combination with quinolines and
arylmethanols, necessitates the urgent development of new anti-malarial drugs to curb the disease. The quinolones are a
promising class of compounds, with some demonstrating potent in vitro activity against the malaria parasite. This review
summarizes the progress made in the development of potential anti-malarial quinolones since 2008. The efficacy of these
compounds against both asexual blood stages and other stages of the malaria parasite, the nature of putative targets,
and a comparison of these properties with anti-malarial drugs currently in clinical use, are discussed
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Beteck, R.M. et al. 2014. Recent progress in the development of anti-malarial quinolones. Malaria journal,13:339-348. [https://doi.org/10.1186/1475-2875-13-339]