Browsing by Subject "monoamine oxidase"

Now showing items 1-3 of 3

    • Inhibition of monoamine oxidase by selected 8–[(phenylsulfanyl)methyl]caffeine derivatives 

      Okaecwe, Thokozile Audrey Dorcas (North-West University, 2012)
      Purpose: Monoamine oxidase (MAO) consists of two isoforms, namely MAO-A and MAO-B. Both these isoforms are involved in the oxidation of dopamine. In Parkinson’s disease (PD) therapy, the inhibition of the oxidation of ...

    • Novel sulfanylphthalimide analogues as highly potent inhibitors of monoamine oxidase B 

      Van der Walt, Mietha M.; Terre'Blanche, Gisella; Petzer, Anél; Petzer, Jacobus P. (Elsevier, 2012)
      Monoamine oxidase (MAO) plays an essential role in the catabolism of neurotransmitter amines. The two isoforms of this enzyme, MAO-A and -B, are considered to be drug targets for the therapy of depression and neurodegenerative ...

    • Selected furanochalcones as inhibitors of monoamine oxidase 

      Robinson, Sarel J.; Petzer, Jacobus P.; Petzer, Anél; Bergh, Jacobus J.; Lourens, Anna C.U. (Elsevier, 2013)
      The validity of the chalcone scaffold for the design of inhibitors of monoamine oxidase has previously been illustrated. In a systematic attempt to investigate the effect of heterocyclic substitution on the monoamine ...