Browsing by Subject "Mycobacterium tuberculosis"
Now showing items 1-10 of 18
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6-Nitro-1-benzylquinolones exhibiting specific antitubercular activity
(Wiley, 2020)In this study, we synthesized novel nitro quinolone‐based compounds and tested them in vitro against a panel of Gram‐positive and Gram‐negative pathogens including Mycobacterium tuberculosis (MTB), Pseudomonas aeruginosa ... -
Anti-mycobacterial peroxides: a new class of agents for development against tuberculosis
(Bentham Science, 2020)Background: With few exceptions, existing tuberculosis drugs were developed many years ago and resistance profiles have emerged. This has created a need for new drugs with discrete modes of action. There is evidence that ... -
A comparison of four sputum pre-extraction preparation methods for identifying and characterising Mycobacterium tuberculosis using GCxGC-TOFMS metabolomics
(Elsevier, 2012)In many pulmonary diseases, sputum is a valuable sample material for use in disease characterisation and diagnostics. However, due to its high viscosity and uneven consistency (lumpiness), it is difficult to obtain ... -
Design, synthesis, and antimycobacterial activity of novel ciprofloxacin derivatives
(Wiley, 2019)Tuberculosis is the deadliest infectious disease affecting humankind with a death toll of approximately 1.7 million people in 2016. The increasing prevalence of multidrug‐resistant strains of the causative pathogen, ... -
Elucidating the antimicrobial mechanisms of colistin on Mycobacterium tuberculosis using metabolomics
(North-West University, 2018)In 2014, the WHO declared tuberculosis (TB) an epidemic, as an estimated 9 million people suffered from Mtb infection. Today, millions of mortalities are still reported worldwide as a result of this disease. This growing ... -
Elucidating the antimicrobial mechanisms of colistin sulfate on Mycobacterium tuberculosis using metabolomics
(Elsevier, 2018)Considering the disadvantageous of first line anti-tuberculosis (TB) drugs, including poor patient adherence, drug side effects, the long treatment duration and rapidly increasing microbe resistance, alternative treatment ... -
Elucidating the antimycobacterial mechanisms of ciprofloxacin and decoquinate derivative RMB041 on Mycobacterium tuberculosis using metabolomics
(North-West University (South Africa), 2022)Tuberculosis (TB) is amongst the leading causes of death brought about by a single infectious agent. Despite all the research done to date since the discovery of the infectious agent, Mycobacterium tuberculosis (Mtb) ... -
The evaluation of the anti‐cancer drug elesclomol that forms a redox‐active copper chelate as a potential anti‐tubercular drug
(Wiley, 2019)The observations that the innate immune system employs copper toeliminate bacterial infection and that resistance to copper enhancesvirulence ofMycobacterium tuberculosis(Mtb) prompted us to exam-ine the effects the ... -
Metabolomics of colistin methanesulfonate treated Mycobacterium tuberculosis
(Elsevier, 2018)Over the past 5 years, there has been a renewed interest in finding new compounds with anti-TB action. Colistin methanesulfonate or polymyxin E, is a possible anti-TB drug candidate, which may in future be used either alone ... -
New insights into the survival mechanisms of rifampicin-resistant Mycobacterium tuberculosis
(Oxford Univ Press, 2016)Objectives: Rifampicin is considered the most important antibiotic for treating TB, but unfortunately Mycobacterium tuberculosis is rapidly developing resistance to this drug. Despite the fervent research efforts to date, ...
