6-Nitro-1-benzylquinolones exhibiting specific antitubercular activity
Date
2020Author
Beteck, Richard M.
Van der Kooy, Frank
Legoabe, Lesetja J.
Jordaan, Audrey
Swart, Tarryn
Metadata
Show full item recordAbstract
In this study, we synthesized novel nitro quinolone‐based compounds and tested them in vitro against a panel of Gram‐positive and Gram‐negative pathogens including Mycobacterium tuberculosis (MTB), Pseudomonas aeruginosa , Acinetobacter baumannii , Klebsiella pneumonia , Staphylococcus aureus , and Escherichia coli for antibacterial activities and also against HeLa cells for overt cytotoxicity. Compound 8e was identified as a non‐toxic, potent hit with selective activity (MIC90 ˂ 0.24 µm ) against MTB. 8e , however, showed no activity against DprE1 mutant, suggesting DprE1 as the likely target for this compound class
URI
http://hdl.handle.net/10394/35507https://onlinelibrary.wiley.com/doi/abs/10.1111/cbdd.13747
https://doi.org/10.1111/cbdd.13747
Collections
- Faculty of Health Sciences [2404]