Browsing by Subject "Multifunctional drugs"
Now showing items 1-2 of 2
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Evaluation of polycyclic amines as modulators of calcium homeostasis in models of neurodegeneration
(North-West University, 2012)Compromised calcium homeostasis in the central nervous system (CNS) is implicated as a major contributor in the pathology of neurodegeneration. Dysregulation of Ca2+ homeostasis initiates downstream Ca2+–dependent events ... -
Synthesis and biological evaluation of pentacycloundecylamines and triquinylamines as voltage-gated calcium channel blockers
(Wiley, 2016)Preclinical studies for neurodegenerative diseases have shown a multi-targeted approach to be successful in the treatment of these complex disorders with several pathoetiological pathways. Polycyclic compounds, such as ...
