Browsing by Subject "LS180"
Now showing items 1-5 of 5
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Characterization of an alginate encapsulated LS180 spheroid model for anti-colorectal cancer compound screening
(ACS, 2020)Colorectal cancer is one of the leading causes of cancer-related deaths. A main problem for its treatment is resistance to chemotherapy, requiring the development of new drugs. The success rate of new candidate cancer drugs ... -
Establishing three-dimensional cell culture models to measure biotransformation and toxicity
(North-West University, Potchefstroom Campus, 2018)A great proportion of new chemical entities will be terminated from the clinical drug development pipeline as a result of deficiencies in drug absorption, distribution, biotransformation and elimination as well as potential ... -
Herb-drug pharmacokinetic interactions: transport and metabolism of indinavir in the presence of selected herbal products
(MDPI, 2015)Patients receiving anti-retroviral drug treatment are sometimes simultaneously taking herbal remedies, which may result in pharmacokinetic herb-drug interactions. This study aimed to determine if pharmacokinetic interactions ... -
Impact of selected herbal products on intestinal epithelial permeation and metabolism of indinavir
(2014)Patients on anti-retroviral (ARV) drug treatment are sometimes simultaneously taking other prescribed drugs and/or over-the-counter drugs and/or herbal remedies. Pharmacokinetic drug-drug or herb-drug interactions can occur ... -
Pharmacokinetic interactions of Aloe vera gel polysaccharides with indinavir
(North-West University (South Africa) , Potchefstroom Campus, 2015)Aloe vera (L.) Burm.f. (Aloe barbadensis Miller) gel and whole leaf materials have shown the ability to modulate the bioavailability of vitamins and to change the transport of molecules across intestinal epithelia. In this ...