Institutional Repository | North-West University | NWU: Recent submissions
Now showing items 8661-8680 of 35800
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Considerations for an in vitro, cell-based testing platform for detection of drug-induced inotropic effects in early drug development. Part 2. Designing and fabricating microsystems for assaying cardiac contractility with physiological relevance using human iPSC-cardiomyocytes
(Frontiers Media, 2019)Contractility of the myocardium engines the pumping function of the heart and is enabled by the collective contractile activity of its muscle cells: cardiomyocytes. The effects of drugs on the contractility of human ... -
A bimodal pollination system enhances reproductive potential of translocated populations of an endangered grassland succulent
(AOSIS, 2019)A major concern during the translocation of higher plant species is related to habitat suitability and the availability of pollination services. Should these not meet the requirements of the plant, then successful reproduction ... -
’n Lewensvaardigheidsprogram vir straatkinders: aanwending van die lewenskaartetegniek in maatskaplike groepwerkverband
(Stellenbosch Univ, 2019)Die artikel dui aan hoe die lewenskaartetegniek as terapeutiese hulpmiddel in maatskaplike groepwerkverband gebruik is om ’n lewensvaardigheidsprogram vir straatkinders te ontwikkel. Hierdie program beoog om die psigo-sosiale ... -
Differences between bone mineral density, lean and fat mass of HIV-positive and HIV-negative black women
(Taylor & Francis, 2019)Objectives: To investigate the differences between bone mineral density (BMD), lean and fat mass of human immunodeficiency virus (HIV-) positive and HIV-negative black women and to investigate factors associated with low ... -
Acute changes in haematocrit leading to polycythaemia in late-onset hypogonadism patients that receive testosterone replacement therapy: a South African study
(Taylor & Francis, 2019)Background: According to the literature, parenteral testosterone replacement therapy (TRT)-induced polycythaemia is associated with cardiovascular events. No or minimal data exist for the prevalence of TRT-induced ... -
Comparative evaluation of molecular based detection methods for drug resistant tuberculosis
(Elsevier, 2019)Tuberculosis (TB) is a globally problematic infectious disease. According to the World Health Organization (WHO) multidrug resistant tuberculosis (MDR-TB) has recently increased by an annual rate of N20%. In 2015; the ... -
The cardiovascular safety of Pheroid® in the conscious rat
(Elsevier, 2019)The Pheroid® technology is a patented colloidal drug delivery system comprised of a dispersed oil phase of omega 3 and omega 6 fatty acids emulsified in N2O saturated water. Pheroid® has pharmaceutical applicability for ... -
Evaluation of the in vitro antimicrobial activity of a Pheroid®- entrapped plant extract against human pathogens
(Elsevier, 2019)This plant extract (PE) has proven activity against fungi affecting crops in South Africa. However, there is currently insufficient data on the activity of the PE against human pathogens. The general aim of this study ... -
Determination of the therapeutic efficacy of a novel Pheroid® formulation in a rodent tuberculosis model
(Elsevier, 2019)Resistance against the current TB treatment regimens is spreading. A combination of the current TB regime with a novel drug delivery system, might lead to reduced resistance, shorter treatment durations and increased ... -
Development of an LC-MS/MS method for the quantification of goserelin from Pheroid® formulation
(Elsevier, 2019)The oral route is for many reasons the most common route of drug administration, however, due to gastrointestinal (GI) tract enzymatic stability issues, peptide drugs are administered parenterally. Goserelin is an ... -
Safety pharmacology of herbal medicines in South Africa
(Elsevier, 2019)The use of herbal medicine for treating various ailments has a deep history in South African traditional medicine. South Africa has a rich floral biodiversity which has been exploited for centuries mainly for day-to-day ... -
Elimination of host and dead pathogenic organism DNA for improved diagnostic outcome
(Elsevier, 2019)Molecular-based diagnostic techniques used to detect bacterial infections in clinical samples are often unable to discriminate between living and dead bacteria and extracellular DNA. This presents a major problem, leading ... -
Development of a batch process to produce ethylated fatty acid esters
(Elsevier, 2019)Pharmaceutical excipients account for the majority of the volume of administered drugs [1]. The problem with the manufacture of pharmaceutical excipients is that they were considered to be inert support material with ... -
Co-administration of African potato and cisplatin for treating breast and prostate cancers using a Pheroid® delivery system
(Elsevier, 2019)The cancer burden is increasing worldwide and is expected tobecome the most important barrier to increasing life expectancy 21stcentury. Low- and middle-income countries are expected to showthe biggest increase in incidence. ... -
Establishment and characterization of allograft and xenograft cancer rodent models
(Elsevier, 2019)To evaluate the efficacy of newly synthesized therapies prior to clinical trials, valid and true cancer models should be used [1]. For modelling cancer in vivo, transplantation of rodent (allograft) and human cancer ... -
Establishment and characterization of a murine HSV-2 model for the evaluation of a novel microbicide
(Elsevier, 2019)Herpes simplex virus −2 (HSV-2) is a serious global epidemic with an estimated 400 million people infected and about 20 million cases reported annually. The prevalence in South Africa is at 31% in females aged 15–29 ... -
The effect of entrapment of a peptide in Pheroid® on pharmacokinetics and testosterone levels
(Elsevier, 2019)Goserelin is a peptide drug that suppresses levels of testosterone and oestradiol [1]. The current formulation is presented in a sustained-release depot with several approved indications such as treatment of endometriosis, ... -
The use of cytokines as indicators for drug safety
(Elsevier, 2019)In developing new compounds, questions about safety and efficacy are raised. Conventional preclinical studies of new compounds focus on bio-distribution, toxicology, safety pharmacology, pharmacokinetics, efficacy etc., ... -
An investigation into the bioavailability of a peroral cannabinoid-Pheroid® formulation
(Elsevier, 2019)Cannabidiol (CBD), a phytocannabinoid isolated from the Cannabis sativa plant, has been investigated for its medicinal properties including anti-psychotic, anti- emetic, anti-inflammatory, anxiolytic and anti- convulsant ... -
Evaluation of the oral delivery of a peptide with Pheroid® technology
(Elsevier, 2019)Goserelin is a type of hormone therapy used in addition to standard adjuvant therapy. Currently, goserelin is only available as a slow releasing subcutaneous implant but this is an invasive and generally not well- tolerated ...
