Predictive utility of European derived genetic variants associated with type 2 diabetes in a black South African population

Abstract

Type 2 diabetes (T2D) is postulated to have a polygenic etiology. Recently, polygenic risk scores of variants associated with T2D have been noted to be of useful in predicting risk in multiple ethnicities as opposed to single variants that have been reported to be population specific. However, the evidence of this phenomenon is limited among the black South Africans. This study was done to determine poly- genic scores associated with T2D and their usefulness in the black South African Population