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The potential use of natural and structural analogues of antimicrobial peptides in the fight against neglected tropical diseases + Erratum

dc.contributor.authorLewies, Angélique
dc.contributor.authorWentzel, Johannes Frederik
dc.contributor.authorJacobs, Garmi
dc.contributor.authorDu Plessis, Lissinda Hester
dc.contributor.researchID20577966 - Lewies, Angélique
dc.contributor.researchID20134045 - Wentzel, Johannes Frederik
dc.contributor.researchID11948388 - Du Plessis, Lissinda Hester
dc.contributor.researchID22119027 - Jacobs, Garmi
dc.date.accessioned2016-08-19T09:01:36Z
dc.date.available2016-08-19T09:01:36Z
dc.date.issued2015
dc.description.abstractRecently, research into the development of new antimicrobial agents has been driven by the increase in resistance to traditional antibiotics and Emerging Infectious Diseases. Antimicrobial peptides (AMPs) are promising candidates as alternatives to current antibiotics in the treatment and prevention of microbial infections. AMPs are produced by all known living species, displaying direct antimicrobial killing activity and playing an important role in innate immunity. To date, more than 2000 AMPs have been discovered and many of these exhibit broad-spectrum antibacterial, antiviral and anti-parasitic activity. Neglected tropical diseases (NTDs) are caused by a variety of pathogens and are particularly wide-spread in low-income and developing regions of the world. Alternative, cost effective treatments are desperately needed to effectively battle these medically diverse diseases. AMPs have been shown to be effective against a variety of NTDs, including African trypanosomes, leishmaniosis and Chagas disease, trachoma and leprosy. In this review, the potential of selected AMPs to successfully treat a variety of NTD infections will be critically evaluateden_US
dc.description.sponsorshipNational Research Foundation (NRF) of South Africaen_US
dc.identifier.citationLewies, A. et al. 2015. The potential use of natural and structural analogues of antimicrobial peptides in the fight against neglected tropical diseases. Molecules, 20(8):15392-15433. [https://doi.org/10.3390/molecules200815392] Erratum: Molecules, 20(9):16757.en_US
dc.identifier.issn1420-3049 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/18334
dc.identifier.urihttp://www.mdpi.com/1420-3049/20/8/15392
dc.identifier.urihttps://doi.org/10.3390/molecules200815392
dc.identifier.uriCorrection: http://www.mdpi.com/1420-3049/20/9/16757
dc.identifier.uriCorrection: https://doi.org/10.3390/molecules200916757
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjectAntimicrobial peptides (AMPs)en_US
dc.subjectNeglected tropical diseases (NTDs)en_US
dc.subjectMalariaen_US
dc.subjectParasitesen_US
dc.subjectAntibacterialen_US
dc.subjectAntiviralen_US
dc.subjectParasitic wormsen_US
dc.subjectInnate immunityen_US
dc.titleThe potential use of natural and structural analogues of antimicrobial peptides in the fight against neglected tropical diseases + Erratumen_US
dc.typeArticleen_US

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