Recent advances in radical C-H bond functionalization of imidazoheterocycles

Abstract

Direct C−H bond functionalization through radical pathway has emerged as a powerful and ideal strategy for the synthesis of organic compounds. This review provides an overview of recent developments in radical C−H functionalization of imidazoheterocycles such as imidazo[1,2‐a]pyridine, benzo[d]imidazo[2,1‐b]thiazole, imidazo[2,1‐b]thiazole, imidazo[1,2‐a]pyrimidine, imidazo[2,1‐a]isoquinoline, imidazo[1,2‐a]pyrazine and imidazo[1,2‐a]quinoline using organic peroxides, photo/electric‐induced protocols, iodine‐based reagents, first‐row transition metal catalysts (Fe, Mn, Ni and Cu) and inorganic oxidants/or salts