Urinary Proteomics and Systems Biology Link Eight Proteins to the Higher Risk of Hypertension and Related Complications in Blacks Versus Whites

Abstract

Blacks are more prone to salt-sensitive hypertension than Whites. This cross-sectional analysis of a multi-ethnic cohort aimedto search for proteins potentially involved in the susceptibility to salt sensitivity, hypertension, and hypertension-relatedcomplications. The study included individuals enrolled in African Prospective Study on the Early Detection and Identificationof Cardiovascular Disease and Hypertension (African-PREDICT), Flemish Study of the Environment, Genes and HealthOutcomes (FLEMENGHO), Prospective Cohort Study in Patients with Type 2 Diabetes Mellitus for Validation of BiomarkerS