Transdermal penetration of zalcitabine, lamivudine and synthesised N-acyl lamivudine ester
| dc.contributor.author | Gerber, Minja | |
| dc.contributor.author | Breytenbach, Jaco C. | |
| dc.contributor.author | Du Plessis, Jeanetta | |
| dc.contributor.researchID | 10059768 - Breytenbach, Jaco Cornelius | |
| dc.contributor.researchID | 10065318 - Du Plessis, Jeanetta | |
| dc.contributor.researchID | 11329025 - Gerber, Minja | |
| dc.date.accessioned | 2010-02-02T05:32:19Z | |
| dc.date.available | 2010-02-02T05:32:19Z | |
| dc.date.issued | 2008 | |
| dc.description.abstract | The objective of this study was to determine the in vitro transdermal permeation through human epidermis of zalcitabine, lamivudine and the synthesised N-acyl lamivudine esters, with and without the use of Pheroid™ as delivery system and to establish a correlation, if any, with selected physicochemical properties. Six N-acyl lamivudine esters were prepared by acylation of lamivudine with six different acid chlorides. The experimental aqueous solubility, log D and in vitro transdermal flux values were determined for these compounds. There was an inverse correlation between the aqueous solubility and the log D values. The median flux of zalcitabine (0.442 μmol/cm2 h) in PBS was lower than that of lamivudine (4.289 μmol/cm2 h), but in Pheroid™, lamivudine (0.011 μmol/cm2 h) had a slightly lower median flux than zalcitabine (0.015 μmol/cm2 h). Entrapment of compounds in Pheroid was confirmed by confocal laser scanning microscopy | |
| dc.identifier.citation | Gerber, M. et al. 2008. Transdermal penetration of zalcitabine, lamivudine and synthesised N-acyl lamivudine esters. International journal of pharmaceutics, 351(1-2):186-193. [https://doi.org/10.1016/j.ijpharm.2007.09.040] | en |
| dc.identifier.issn | 0378-5173 | |
| dc.identifier.uri | http://hdl.handle.net/10394/2784 | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0378517307008198 | |
| dc.identifier.uri | https://doi.org/10.1016/j.ijpharm.2007.09.040 | |
| dc.language.iso | en | en |
| dc.publisher | Elsevier | en |
| dc.subject | Zalcitabine | |
| dc.subject | Lamivudine | |
| dc.subject | N-acyl lamivudine esters | |
| dc.subject | Skin penetration | |
| dc.subject | Transdermal delivery | |
| dc.title | Transdermal penetration of zalcitabine, lamivudine and synthesised N-acyl lamivudine ester | en |
| dc.type | Article | en |