Bestudering van die effek van Sagatal R (Natriumpentobarbituraat) op skeletspier sarkoplasmiese retikulumfunksie

Abstract

Barbiturates influence the functions of sarcoplasmic reticulum (SR) membranes. It has been shown that pentobarbital as well as other barbiturates caused a reduction in the phase transition temperatures (Lee, 1976) and thus it may alter the fluidity of the membrane phospholipids. Low et al . (1979) has shown that sodium pentobarbit91 displaces Ca 2 + from their binding sites in red blood cell membranes while halothane (Diamond & Berman, 1980) competes with ATP for binding to the SR membrane. Experiments performed by Saida & Suzuki (1981) suggest that prilocaine presumably is able to depolarize the SR membrane, causing rapid Ca 2 + release. It has been documented by Lain et al. (1968) that pentobarbital inhibits Ca 2 + uptake by cardiac SR less than it affects cardiac contractility. From these reports it seems that anaesthetics like pentobarbital sodium may affect membranes like the sarcoplasmic reticulum in various ways.