Isolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico-striatal oxidative stress, and reversed by sub-chronic clozapine administration
| dc.contributor.author | Möller, Marisa | |
| dc.contributor.author | Du Preez, Jan L. | |
| dc.contributor.author | Harvey, Brian Herbert | |
| dc.contributor.author | Emsley, Robin | |
| dc.contributor.researchID | 10060510 - Du Preez, Jan Lourens | |
| dc.contributor.researchID | 11083417 - Harvey, Brian Herbert | |
| dc.contributor.researchID | 21247250 - Möller Wolmarans, Marisa | |
| dc.date.accessioned | 2012-10-05T07:23:02Z | |
| dc.date.available | 2012-10-05T07:23:02Z | |
| dc.date.issued | 2011 | |
| dc.description | The journal of the European College of Neuropsychopharmacology | en_US |
| dc.description.abstract | Social isolation rearing (SIR) in rats induces behavioral and glutamatergic changes akin to schizophrenia. We studied the effects of 8 weeks SIR on cortico-striatal redox and social and cognitive behaviors in rats. SIR increased superoxide dismutase activity, decreased oxidized:reduced glutathione ratio and increased lipid peroxidation in both brain regions, and induced deficits in prepulse inhibition and social and self-directed interactive behaviors. Both behavioral and cortico-striatal redox disturbances were corrected by clozapine (5 mg/kg/day × 11 days). Behavioral changes evoked by SIR are associated with cortico-striatal oxidative stress that is reversed by clozapine treatment, providing novel insight into the neurobiology and treatment of schizophrenia. | en_US |
| dc.identifier.citation | Möller, M. et al. 2011. Isolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico-striatal oxidative stress, and reversed by sub-chronic clozapine administration. European neuropsychopharmacology, 21(6):471-483. [https://doi.org/10.1016/j.euroneuro.2010.09.006] | en_US |
| dc.identifier.issn | 0924-977X | |
| dc.identifier.issn | 1873-7862 (Online) | |
| dc.identifier.uri | http://hdl.handle.net/10394/7441 | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0924977X1000194X | |
| dc.identifier.uri | https://doi.org/10.1016/j.euroneuro.2010.09.006 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier | en_US |
| dc.subject | Social isolation | en_US |
| dc.subject | Prepulse inhibition | en_US |
| dc.subject | Social interaction | en_US |
| dc.subject | Clozapine | en_US |
| dc.subject | Schizophrenia | en_US |
| dc.subject | Animal model | en_US |
| dc.subject | Oxidative stress | en_US |
| dc.title | Isolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico-striatal oxidative stress, and reversed by sub-chronic clozapine administration | en_US |
| dc.type | Article | en_US |