Editorial - The importance of glycemic control in regulating clot properties in CAD patients with concomitant diabetes

Abstract

Densely packed clots with a stiffer network arrangement, reduced pore size and increased resistance to lysis have been consistently found in a variety of cardiovascular diseases, including arterial thrombotic, venous thrombotic, and thromboembolic diseases, as well as in atherosclerosis itself [1]. In addition, recent prospective evidence suggests a causal role for this type of clot structure in predicting disease severity and outcomes, such as increased mortality in acute coronary syndrome (ACS) patients, recurrent deep vein thrombosis in first-event patients, and recurrent thromboembolic events in antiphospholipid syndrome [reviewed by 1].