Artemisinin quinoline hybrid-dimers: synthesis and in vitro antiplasmodial activity
| dc.contributor.author | Lombard, Marli C. | en_US |
| dc.contributor.author | N'Da, David D. | en_US |
| dc.contributor.author | Breytenbach, Jaco C. | en_US |
| dc.contributor.author | Smith, Peter J. | en_US |
| dc.contributor.author | Lategan, Carmen A. | |
| dc.contributor.researchID | 20883072 - N'Da, David Dago | |
| dc.contributor.researchID | 10059768 - Breytenbach, Jaco Cornelius | |
| dc.date.accessioned | 2012-02-29T09:49:47Z | |
| dc.date.available | 2012-02-29T09:49:47Z | |
| dc.date.issued | 2010 | en_US |
| dc.description.abstract | Novel artemisinin-quinoline hybrid-dimers were synthesized from dihydroartemisinin and different aminoquinolines at elevated temperatures (90-110 °C). All compounds were obtained as the β-isomers and were tested against both chloroquine sensitive and resistant strains of Plasmodium falciparum. Hybrid-dimer 8 showed the highest antiplasmodial activity, inheriting the optimum chain length of three carbon atoms | |
| dc.identifier.citation | Lombard, M.C. et al. 2010. Artemisinin quinoline hybrid-dimers: synthesis and in vitro antiplasmodial activity. Bioorganic & medicinal chemistry letters, 20(23):6975-697. [https://doi.org/10.1016/j.bmcl.2010.09.130] | en_US |
| dc.identifier.issn | 0960-894X | en_US |
| dc.identifier.issn | 0968-0896 (Online) | en_US |
| dc.identifier.uri | http://hdl.handle.net/10394/5974 | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0960894X10014393 | |
| dc.identifier.uri | https://doi.org/10.1016/j.bmcl.2010.09.130 | |
| dc.language | en | |
| dc.publisher | Elsevier | en_US |
| dc.subject | Malaria | |
| dc.subject | Dihydroartemisinin | |
| dc.subject | Quinoline | |
| dc.subject | Hybrid | |
| dc.subject | Dimer | |
| dc.title | Artemisinin quinoline hybrid-dimers: synthesis and in vitro antiplasmodial activity | en_US |