Antioxidant properties of 4-quinolones and structurally related flavones
Date
2012Author
Greeff, Jane
Van Dyk, Sandra
Malan, Sarel F.
Joubert, Jacques
Metadata
Show full item recordAbstract
Neurodegenerative disorders are frequently associated with increased oxidative damage to the brain as a result of free radicals produced by cellular respiration. The onset and progression of neurodegeneration may therefore be curbed by exogenous hydrogen-donating antioxidant moieties such as the naturally occurring flavonoids. A series of 2-phenylquinolin-4(1H)-ones was synthesised and displayed moderate to high antioxidant activity when compared to structurally related flavones and quinolines. Activity of the hydroxy-2-phenylquinolin-4(1H)-ones (8–10) was established in reducing ferrous ions and diminishing hydrogen peroxide and hydroxyl radical production, in the FRAP (1.41–97.71% Trolox® equivalents), ORAC (9.18–15.27 μM Trolox® equivalents at 0.001 mM) and TBARS (0.05–0.72 nmol MDA/mg tissue) assays, respectively. The results indicated that the additional hydrogen donating groups on the synthesised 2-phenylquinolin-4(1H)-one series increased antioxidant activity.
URI
http://hdl.handle.net/10394/9886https://www.sciencedirect.com/science/article/pii/S0968089611010042
https://doi.org/10.1016/j.bmc.2011.11.068
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- Faculty of Health Sciences [2386]