In vitro efficacy of synthesized artemisinin derivatives against Leishmania promastigotes
Abstract
Leishmaniasis is a neglected tropical disease affecting thousands worldwide, especially in developing countries where it co-exists with malaria. Only a handful of drugs are clinically available to treat the disease, but significant limitations threaten their very use. New, safe and effective drugs, including those against malaria-leishmaniasis co-infections, are thus imperative. We assessed the in vitro anti-infective potential of previously synthesized, potent antimalarial artemisinin derivatives. Analogue esters featuring 1,1′-biphenyl and thiophenyl moieties were as much as 30-fold more potent than clinical artemisinins against L. donovani parasites, qualifying them as antipromastigote hits for further investigation in the search for malaria-leishmaniasis co-infection therapies
URI
http://hdl.handle.net/10394/35967https://www.sciencedirect.com/science/article/pii/S0960894X20306922
https://doi.org/10.1016/j.bmcl.2020.127581
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- Faculty of Health Sciences [2386]