• Login
    View Item 
    •   NWU-IR Home
    • Research Output
    • Faculty of Natural and Agricultural Sciences
    • View Item
    •   NWU-IR Home
    • Research Output
    • Faculty of Natural and Agricultural Sciences
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Anticancer activity, apoptosis and a structure-activity analysis of a series of 1,4-naphthoquinone-2,3-bis-sulfides

    Thumbnail
    Date
    2020
    Author
    Wellington, Kevin W.
    Motadi, Lesetja R.
    Kolesnikova, Natasha I.
    Hlatshwayo, Vincent
    Saha, Sourav T.
    Metadata
    Show full item record
    Abstract
    We have previously reported on the synthesis of 1,4-naphthoquinone-sulfides and in this investigation we report on their anticancer activity against 6 human cancer cell lines to evaluate their cytostatic effects. The 1,4-naphthoquinone-2,3-bis-sulfides were most effective against melanoma (UACC62) (GI50 = 6.5–10 μM) and prostate (PC3) (GI50 = 5.51–8.53 μM) cancer cell lines. They exhibited better cytostatic effects than etoposide (GI50 = 0.56–36.62 μM), parthenolide (GI50 = 3.58–25.97 μM) and VK3 (GI50 = 3.41–22.59 μM) against several of the cancer cell lines. These compounds are generally more selective for cancer cells than for normal human lung fetal fibroblasts (WI-38). One compound produces ROS which results in breast (MCF7) cancer cell death caused by apoptosis as evidenced by caspase 3/7 activation. Apoptosis was found to occur by a mitochondrial pathway and not by cell cycle arrest. Gene expression studies showed that p53 (a tumour suppressor), Mdm-2 (a p53 regulator) and Bcl-2 (apoptosis inhibitor) were up-regulated during apoptosis induction. These results encourage further research for potential application in cancer chemotherapy
    URI
    http://hdl.handle.net/10394/34795
    https://link.springer.com/article/10.1007/s10637-019-00775-7
    https://doi.org/10.1007/s10637-019-00775-7
    Collections
    • Faculty of Natural and Agricultural Sciences [4788]

    Copyright © North-West University
    Contact Us | Send Feedback
    Theme by 
    Atmire NV
     

     

    Browse

    All of NWU-IR Communities & CollectionsBy Issue DateAuthorsTitlesSubjectsAdvisor/SupervisorThesis TypeThis CollectionBy Issue DateAuthorsTitlesSubjectsAdvisor/SupervisorThesis Type

    My Account

    LoginRegister

    Copyright © North-West University
    Contact Us | Send Feedback
    Theme by 
    Atmire NV