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dc.contributor.authorDu Plessis, Jacomina P.
dc.contributor.authorMelse-Boonstra, Alida
dc.contributor.authorZandberg, Lizelle
dc.contributor.authorNienaber-Rousseau, Cornelie
dc.date.accessioned2020-01-24T08:00:25Z
dc.date.available2020-01-24T08:00:25Z
dc.date.issued2020
dc.identifier.citationDu Plessis, J.P. et al. 2020. Gene interactions observed with the HDL-c blood lipid, intakes of protein, sugar and biotin in relation to circulating homocysteine concentrations in a group of black South Africans. Molecular genetics and metabolism reports, 22: # 100556. [https://doi.org/10.1016/j.ymgmr.2019.100556]en_US
dc.identifier.issn2214-4269 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/33946
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S2214426919302010
dc.identifier.urihttps://doi.org/10.1016/j.ymgmr.2019.100556
dc.description.abstractBackground Elevated homocysteine (Hcy) is associated with several pathologies. Gene–diet interactions related to Hcy might be used to customize dietary advice to reduce disease incidence. To explore this possibility, we investigated interactions between anthropometry, biochemical markers and diet and single-nucleotide polymorphisms (SNPs) in relation to Hcy concentrations. Five SNPs of Hcy-metabolizing enzymes were analyzed in 2010 black South Africans. Results Hcy was higher with each additional methylenetetrahydrofolate reductase (MTHFR) C677T minor allele copy, but was lower in methionine synthase (MTR) 2756AA homozygotes than heterozygotes. Individuals harboring cystathionine β synthase (CBS) 833 T/844ins68 had lower Hcy concentrations than others. No interactive effects were observed with any of the anthropometrical markers. MTHFR C677T and CBS T833C/844ins68 homozygote minor allele carriers presented with lower Hcy as high density lipoprotein cholesterol (HDL-c) increased. Hcy concentrations were negatively associated with dietary protein and animal protein intake in the TT and TC genotypes, but positively in the CC genotype of CBS T833C/844ins68. Hcy was markedly higher in TT homozygotes of MTHFR C677T as added sugar intake increased. In CBS T833C/844ins68 major allele carriers, biotin intake was negatively associated with Hcy; but positively in those harboring the homozygous minor allele. Conclusions The Hcy–SNP associations are modulated by diet and open up the possibility of invoking dietary interventions to treat hyperhomocysteinemia. Future intervention trials should further explore the observed gene–diet and gene–blood lipid interactionsen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectBiotinen_US
dc.subjectBlood lipid-gene interactionsen_US
dc.subjectGene-diet interactionsen_US
dc.subjectHyperhomocysteinemiaen_US
dc.subjectNutrient-gene interactionsen_US
dc.subjectNutrigeneticsen_US
dc.subjectPrecision nutritionen_US
dc.subjectProteinen_US
dc.subjectSugaren_US
dc.subjectTotal homocysteineen_US
dc.titleGene interactions observed with the HDL-c blood lipid, intakes of protein, sugar and biotin in relation to circulating homocysteine concentrations in a group of black South Africansen_US
dc.typeArticleen_US
dc.contributor.researchID12257656 - Zandberg, Lizelle
dc.contributor.researchID12632449 - Nienaber-Rousseau, Cornelie
dc.contributor.researchID23446307 - Du Plessis, Jacomina P.
dc.contributor.researchID20338457 - Melse-Boonstra, Alida


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