dc.contributor.author | Gafane-Matemane, Lebo F. | |
dc.contributor.author | Mokae, Nametsegang L. | |
dc.contributor.author | Breet, Yolandi | |
dc.contributor.author | Malan, Leoné | |
dc.date.accessioned | 2019-10-21T07:29:04Z | |
dc.date.available | 2019-10-21T07:29:04Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Gafane-Matemane, L.F. et al. 2020. Relation of the renin-angiotensin-aldosterone system with potential cardiac injury and remodelling: the SABPA study. Blood pressure, 29(1):31-38. [https://doi.org/10.1080/08037051.2019.1645587] | en_US |
dc.identifier.issn | 0803-7051 | |
dc.identifier.issn | 1651-1999 (Online) | |
dc.identifier.uri | http://hdl.handle.net/10394/33441 | |
dc.identifier.uri | https://www.tandfonline.com/doi/full/10.1080/08037051.2019.1645587 | |
dc.identifier.uri | https://doi.org/10.1080/08037051.2019.1645587 | |
dc.description.abstract | Purpose: The renin-angiotensin-aldosterone system (RAAS) plays an important role in maintaining hemodynamic homeostasis. Ethnic disparities exist regarding RAAS activity due to sympathetic activity and sodium-water retention, however the implications thereof on cardiac damage is unknown. This study investigated the associations of cardiac troponin T (cTnT), N-terminal pro-brain natriuretic peptide (NTproBNP) and subclinical LVH with components of the RAAS (renin, aldosterone and aldosterone-to-renin ratio (ARR)) and copeptin in a black and white South African cohort.
Materials and methods: The study population consisted of 305 participants (black = 139, white = 166) aged 20–62 years. Serum cTnT, NTproBNP, Cornell product, components of the RAAS (active renin, aldosterone and ARR) and copeptin were determined.
Results: The black group had lower renin (p < 0.001) and higher ARR (p < 0.001), cTnT (p = 0.015) and Cornell product compared to whites (all p < 0.001). NTproBNP and copeptin were similar between the groups. After forward stepwise adjustments for multiple confounders, inverse associations of cTnT with renin (β = −0.17, p = 0.018) and aldosterone (β = −0.14, p = 0.048) as well as an inverse association between NTproBNP and aldosterone (β = −0.25, p < 0.001) were observed in the white population only. In the black group cTnT associated positively with renin (β = 0.16, p = 0.040) and copeptin (β = 0.21, p = 0.020) and inversely with ARR (β = −0.15, p = 0.047). Additionally, NTproBNP associated positively with copeptin (β = 0.18, p = 0.045). No correlations were observed between the RAAS and Cornell product in any of the groups.
Conclusions: Our findings suggest that RAAS, together with cardiac stress may function differently in cardiac damage and remodelling in the two ethnic groups; which may influence treatment in clinical practice | en_US |
dc.language.iso | en | en_US |
dc.publisher | Taylor & Francis | en_US |
dc.subject | Cardiac injury | en_US |
dc.subject | Cardiac troponin T | en_US |
dc.subject | Cardiac remodelling | en_US |
dc.subject | NTproBNP | en_US |
dc.subject | Renin | en_US |
dc.subject | Aldosterone | en_US |
dc.subject | Copeptin | en_US |
dc.title | Relation of the renin-angiotensin-aldosterone system with potential cardiac injury and remodelling: the SABPA study | en_US |
dc.type | Article | en_US |
dc.contributor.researchID | 10060871 - Malan, Leoné | |
dc.contributor.researchID | 21195706 - Breet, Yolandi | |
dc.contributor.researchID | 24341185 - Gafane-Matemane, Lebo Francina | |
dc.contributor.researchID | 25130412 - Mokae, Nametsegang Lorato | |