Show simple item record

dc.contributor.authorGafane-Matemane, Lebo F.
dc.contributor.authorMokae, Nametsegang L.
dc.contributor.authorBreet, Yolandi
dc.contributor.authorMalan, Leoné
dc.date.accessioned2019-10-21T07:29:04Z
dc.date.available2019-10-21T07:29:04Z
dc.date.issued2020
dc.identifier.citationGafane-Matemane, L.F. et al. 2020. Relation of the renin-angiotensin-aldosterone system with potential cardiac injury and remodelling: the SABPA study. Blood pressure, 29(1):31-38. [https://doi.org/10.1080/08037051.2019.1645587]en_US
dc.identifier.issn0803-7051
dc.identifier.issn1651-1999 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/33441
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/08037051.2019.1645587
dc.identifier.urihttps://doi.org/10.1080/08037051.2019.1645587
dc.description.abstractPurpose: The renin-angiotensin-aldosterone system (RAAS) plays an important role in maintaining hemodynamic homeostasis. Ethnic disparities exist regarding RAAS activity due to sympathetic activity and sodium-water retention, however the implications thereof on cardiac damage is unknown. This study investigated the associations of cardiac troponin T (cTnT), N-terminal pro-brain natriuretic peptide (NTproBNP) and subclinical LVH with components of the RAAS (renin, aldosterone and aldosterone-to-renin ratio (ARR)) and copeptin in a black and white South African cohort. Materials and methods: The study population consisted of 305 participants (black = 139, white = 166) aged 20–62 years. Serum cTnT, NTproBNP, Cornell product, components of the RAAS (active renin, aldosterone and ARR) and copeptin were determined. Results: The black group had lower renin (p < 0.001) and higher ARR (p < 0.001), cTnT (p = 0.015) and Cornell product compared to whites (all p < 0.001). NTproBNP and copeptin were similar between the groups. After forward stepwise adjustments for multiple confounders, inverse associations of cTnT with renin (β = −0.17, p = 0.018) and aldosterone (β = −0.14, p = 0.048) as well as an inverse association between NTproBNP and aldosterone (β = −0.25, p < 0.001) were observed in the white population only. In the black group cTnT associated positively with renin (β = 0.16, p = 0.040) and copeptin (β = 0.21, p = 0.020) and inversely with ARR (β = −0.15, p = 0.047). Additionally, NTproBNP associated positively with copeptin (β = 0.18, p = 0.045). No correlations were observed between the RAAS and Cornell product in any of the groups. Conclusions: Our findings suggest that RAAS, together with cardiac stress may function differently in cardiac damage and remodelling in the two ethnic groups; which may influence treatment in clinical practiceen_US
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.subjectCardiac injuryen_US
dc.subjectCardiac troponin Ten_US
dc.subjectCardiac remodellingen_US
dc.subjectNTproBNPen_US
dc.subjectReninen_US
dc.subjectAldosteroneen_US
dc.subjectCopeptinen_US
dc.titleRelation of the renin-angiotensin-aldosterone system with potential cardiac injury and remodelling: the SABPA studyen_US
dc.typeArticleen_US
dc.contributor.researchID10060871 - Malan, Leoné
dc.contributor.researchID21195706 - Breet, Yolandi
dc.contributor.researchID24341185 - Gafane-Matemane, Lebo Francina
dc.contributor.researchID25130412 - Mokae, Nametsegang Lorato


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record