Erythrocyte membrane fatty acids in patients with multiple sclerosis

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Date
2009
Author
Smuts, Cornelius
Hon, G.M.
Hassan, M.S.
Van Rensburg, S.J.
Abel, S.
Marais, D.W.
Van Jaarsveld, P.
Henning, F.
Erasmus, R.T.
Matsha, T.
Hon, G.M.
Hassan, M.S.
Van Rensburg, S.J.
Abel, S.
Marais, D.W.
Van Jaarsveld, P.
Henning, F.
Erasmus, R.T.
Matsha, T.
Smuts, Cornelius
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Abstract
BACKGROUND: Reports on fatty acids levels in multiple sclerosis remain inconclusive. OBJECTIVE: To determine the erythrocyte membrane fatty acid levels in multiple sclerosis patients and correlate with Kurtzke Expanded Disability Status Scale. METHODS: Fatty acid composition of 31 multiple sclerosis and 30 control individuals were measured by gas chromatography. RESULTS: The membrane phosphatidylcholine C20:4n - 6 concentration was lower in the multiple sclerosis patients when compared to that of the control group, P = 0.04 and it correlated inversely with the EDSS and FSS. CONCLUSION: Decrease in C20:4n - 6 in the erythrocyte membrane could be an indication of depleted plasma stores, and a reflection of disease severity.
URI
http://hdl.handle.net/10394/3336
https://doi.org/10.1177/1352458509103321
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