Erythrocyte membrane fatty acids in patients with multiple sclerosis
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SAGE Publications
Abstract
BACKGROUND:
Reports on fatty acids levels in multiple sclerosis remain inconclusive.
OBJECTIVE:
To determine the erythrocyte membrane fatty acid levels in multiple sclerosis patients and correlate with Kurtzke Expanded Disability Status Scale.
METHODS:
Fatty acid composition of 31 multiple sclerosis and 30 control individuals were measured by gas chromatography.
RESULTS:
The membrane phosphatidylcholine C20:4n - 6 concentration was lower in the multiple sclerosis patients when compared to that of the control group, P = 0.04 and it correlated inversely with the EDSS and FSS.
CONCLUSION:
Decrease in C20:4n - 6 in the erythrocyte membrane could be an indication of depleted plasma stores, and a reflection of disease severity.
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Citation
Smuts, C. et al. 2009. Erythrocyte membrane fatty acids in patients with multiple sclerosis. Multiple Sclerosis, 15(6):759-62, Jun. [https://doi.org/10.1177/1352458509103321]