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dc.contributor.authorGerber, Werner
dc.contributor.authorSteyn, Dewald
dc.contributor.authorKotzé, Awie
dc.contributor.authorSvitina, Hanna
dc.contributor.authorWeldon, Ché
dc.contributor.authorHamman, Josias
dc.identifier.citationGerber, W. et al. 2019. Capsaicin and piperine as functional excipients for improved drug delivery across nasal epithelial models. Planta medica, 85(3):1114-1123. []en_US
dc.identifier.issn1439-0221 (Online)
dc.description.abstractThe fruit from various pepper plants has been employed for the seasoning of food, as perfuming agents, and also as traditional medicines. Phytochemicals isolated from different pepper species have been found to modulate the pharmacokinetics of orally administered drugs. This study investigated the possibility to apply capsaicin and piperine (extracted alkaloids) as modulators for drug delivery across the nasal epithelium. Both a nasal epithelial cell line (RPMI 2650) and excised sheep nasal tissue were used as models to investigate the effects of the selected pepper compounds on drug permeation. FITC-dextran 4400 (MW 4400 Da) was used as a large molecular weight marker compound for paracellular transport, while rhodamine 123 was used as a marker compound that is a substrate for P-glycoprotein-mediated efflux. From the permeation results, it was clear that capsaicin inhibited P-glycoprotein efflux to a larger extent, while piperine showed drug permeation enhancement via other mechanisms. The cell cytotoxicity studies indicated that capsaicin was noncytotoxic up to a concentration of 200 µM and piperine up to a concentration of 500 µM as indicated by cell viability above 80%. The histological analysis of the excised nasal tissue and cultured RPMI 2650 cell layers indicated that some damage occurred after treatment with 200 µM capsaicin, but no changes were observed for piperine up to a concentration of 50 µMen_US
dc.subjectFITC-dextran 4400en_US
dc.subjectRhodamine 123en_US
dc.subjectRPMI 2650en_US
dc.subjectNasal deliveryen_US
dc.titleCapsaicin and piperine as functional excipients for improved drug delivery across nasal epithelial modelsen_US
dc.contributor.researchID22117040 - Gerber, Werner
dc.contributor.researchID12297305 - Steyn, Johan Dewald
dc.contributor.researchID10200142 - Kotzé, Abraham Frederik
dc.contributor.researchID10081097 - Hamman, Josias Hendrik
dc.contributor.researchID12384488 - Weldon, Ché
dc.contributor.researchID30884365 - Svitina, Hanna M.

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