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dc.contributor.authorMüller-Nedebock, Amica C.
dc.contributor.authorVenter, Marianne
dc.contributor.authorVan der Westhuizen, Francois H.
dc.contributor.authorElson, Joanna L.
dc.contributor.authorBrennan, Rebecca R.
dc.date.accessioned2019-07-22T09:34:09Z
dc.date.available2019-07-22T09:34:09Z
dc.date.issued2019
dc.identifier.citationMüller-Nedebock, A.C. et al. 2019. The unresolved role of mitochondrial DNA in Parkinson's disease: an overview of published studies, their limitations, and future prospects. Neurochemistry international, 129: Article no 104495. [https://doi.org/10.1016/j.neuint.2019.104495]en_US
dc.identifier.issn0197-0186
dc.identifier.issn1872-9754 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/32936
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0197018619302207
dc.identifier.urihttps://doi.org/10.1016/j.neuint.2019.104495
dc.description.abstractParkinson's disease (PD), a progressive neurodegenerative disorder, has long been associated with mitochondrial dysfunction in both sporadic and familial forms of the disease. Mitochondria are crucial for maintaining cellular homeostasis, and their dysfunction is detrimental to dopaminergic neurons. These neurons are highly dependent on mitochondrial adenosine triphosphate (ATP) and degenerate in PD. Mitochondria contain their own genomes (mtDNA). The role of mtDNA has been investigated in PD on the premise that it encodes vital components of the ATP-generating oxidative phosphorylation (OXPHOS) complexes and accumulates somatic variation with age. However, the association between mtDNA variation and PD remains controversial. Herein, we provide an overview of previously published studies on the role of inherited as well as somatic (acquired) mtDNA changes in PD including point mutations, deletions and depletion. We outline limitations of previous investigations and the difficulties associated with studying mtDNA, which have left its role unresolved in the context of PD. Lastly, we highlight the potential for further research in this field and provide suggestions for future studies. Overall, the mitochondrial genome is indispensable for proper cellular function and its contribution to PD requires further, more extensive investigationen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectParkinson's diseaseen_US
dc.subjectMitochondrial DNAen_US
dc.subjectMitochondrial haplogroupsen_US
dc.subjectSomatic mtDNA variationen_US
dc.subjectHomoplasmic mtDNA variationen_US
dc.subjectmtDNA depletionen_US
dc.titleThe unresolved role of mitochondrial DNA in Parkinson's disease: an overview of published studies, their limitations, and future prospectsen_US
dc.typeArticleen_US
dc.contributor.researchID10213503 - Van der Westhuizen, Francois Hendrikus
dc.contributor.researchID24952338 - Elson, Joanna L.


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