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dc.contributor.authorDe Bruyn, Suzette
dc.contributor.authorWillers, Clarissa
dc.contributor.authorSteyn, Dewald
dc.contributor.authorSteenekamp, Jan
dc.contributor.authorHamman, Josias
dc.date.accessioned2019-07-17T11:31:56Z
dc.date.available2019-07-17T11:31:56Z
dc.date.issued2018
dc.identifier.citationDe Bruyn, S. et al. 2018. Development and evaluation of a double-phase multiple-unit dosage form for enhanced insulin intestinal delivery. Drug delivery letters, 8(1):52-60. [https://doi.org/10.2174/2210303107666170928125212]en_US
dc.identifier.issn2210-3031
dc.identifier.issn2210-304X (Online)
dc.identifier.urihttp://hdl.handle.net/10394/32900
dc.identifier.urihttp://www.eurekaselect.com/155954/article
dc.identifier.urihttps://doi.org/10.2174/2210303107666170928125212
dc.description.abstractBackground: The oral route is the most preferred route of administration for selfmedication, but poor membrane permeability and pre-systemic degradation are key challenges that need to be addressed. Objective: The purpose of this study was to develop and evaluate a double-phase, multiple-unit dosage form for enhanced delivery of insulin across the gastrointestinal tract epithelium. The dosage form was designed to provide increased membrane permeation by opening of tight junctions during the first phase followed by insulin delivery during the second phase. Methods: Different beads were prepared by means of extrusion-spheronisation. Combinations of different beads constituted the double-phase drug delivery systems. The one type of bead contained insulin as active ingredient and chitosan as mucoadhesive agent, while the other bead formulations contained each one of the following drug absorption enhancers: a bile salt mixture, sodium glycocholate, Aloe vera whole leaf extract or Aloe vera gel. The insulin delivery performance of the different doublephase delivery systems was evaluated across excised pig intestinal tissues in a Sweetana-Grass diffusion apparatus. Results: Initial exposure of the excised pig intestinal tissues to the absorption enhancer containing beads (first phase) was associated with enhanced intestinal transport of insulin (second phase) when compared to the control group. The insulin permeation enhancement effect across excised pig intestinal tissue was statistically significant in the case of pre-exposure to A. vera whole leaf extract and A. vera gel containing beads. Conclusion: Several double-phase multiple-unit drug delivery systems have the potential to effectively deliver insulin across the gastrointestinal epitheliumen_US
dc.language.isoenen_US
dc.publisherBentham Scienceen_US
dc.subjectAloe veraen_US
dc.subjectBile salten_US
dc.subjectChitosanen_US
dc.subjectExtrusion-spheronisationen_US
dc.subjectInsulinen_US
dc.subjectParacellular permeationen_US
dc.subjectPermeation enhancementen_US
dc.subjectSodium glycocholateen_US
dc.subjectTight junction
dc.titleDevelopment and evaluation of a double-phase multiple-unit dosage form for enhanced insulin intestinal deliveryen_US
dc.typeArticleen_US
dc.contributor.researchID10081097 - Hamman, Josias Hendrik
dc.contributor.researchID20672322 - Willers, Clarissa
dc.contributor.researchID12297305 - Steyn, Johan Dewald
dc.contributor.researchID10096078 - Steenekamp, Jan Harm
dc.contributor.researchID22140883 - De Bruyn, Suzette


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