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dc.contributor.authorZabegalov, Konstantin N.
dc.contributor.authorHarvey, Brian H.
dc.contributor.authorKhatsko, Sergey L.
dc.contributor.authorLakstygal, Anton M.
dc.contributor.authorDemin, Konstantin A.
dc.date.accessioned2019-05-20T10:52:45Z
dc.date.available2019-05-20T10:52:45Z
dc.date.issued2019
dc.identifier.citationZabegalov, K.N. et al. 2019. Abnormal repetitive behaviors in zebrafish and their relevance to human brain disorders. Behavioural brain research, 367:101-110. [https://doi.org/10.1016/j.bbr.2019.03.044]en_US
dc.identifier.issn0166-4328
dc.identifier.issn1872-7549 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/32395
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0166432818315912
dc.identifier.urihttps://doi.org/10.1016/j.bbr.2019.03.044
dc.description.abstractAbnormal repetitive behaviors (ARBs) are a prominent symptom of numerous human brain disorders and are commonly seen in rodent models as well. While rodent studies of ARBs continue to dominate the field, mounting evidence suggests that zebrafish (Danio rerio) also display ARB-like phenotypes and may therefore be a novel model organism for ARB research. In addition to clear practical research advantages as a model species, zebrafish share high genetic and physiological homology to humans and rodents, including multiple ARB-related genes and robust behaviors relevant to ARB. Here, we discuss a wide spectrum of stereotypic repetitive behaviors in zebrafish, data on their genetic and pharmacological modulation, and the overall translational relevance of fish ARBs to modeling human brain disorders. Overall, the zebrafish is rapidly emerging as a new promising model to study ARBs and their underlying mechanismsen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectZebrafishen_US
dc.subjectAbnormal repetitive behavioren_US
dc.subjectStereotypyen_US
dc.subjectAnimal modelsen_US
dc.subjectHuman brain disordersen_US
dc.titleAbnormal repetitive behaviors in zebrafish and their relevance to human brain disordersen_US
dc.typeArticleen_US
dc.contributor.researchID11083417 - Harvey, Brian Herbert


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