dc.contributor.author | Salas, Maribel | |
dc.contributor.author | Burger, Johanita | |
dc.contributor.author | Lopes, Luciane C. | |
dc.contributor.author | Godman, Brian | |
dc.contributor.author | Truter, Ilse | |
dc.date.accessioned | 2019-04-16T13:22:59Z | |
dc.date.available | 2019-04-16T13:22:59Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Salas, M. et al. 2018. Challenges and issues in drug utilization research identified from the Latin American and African regions. Abstracts of the 34th International Conference on Pharmacoepidemiology & Therapeutic Risk Management, Prague Congress Centre, Prague, Czech Republic, Aug 22‐26, 2018. Meeting abstract: 903. Pharmacoepidemiology and drug safety, 27(Suppl2): 413-414. [https://doi.org/https://doi.org/10.1002/pds.4629] | en_US |
dc.identifier.issn | 1053-8569 | |
dc.identifier.issn | 1099-1557 (Online) | |
dc.identifier.uri | http://hdl.handle.net/10394/32228 | |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/10.1002/pds.4629 | |
dc.identifier.uri | https://doi.org/https://doi.org/10.1002/pds.4629 | |
dc.description.abstract | Background: Despite advancements in drug utilization research (DUR),
these have not been universal. Some regions such as the Latin America
(LatAm) and African regions are facing challenges that are impeding
the development of DUR.
Objectives: To identify the main challenges and issues for DUR in the
LatAm and African regionsMethods: A collaborative initiative by the
International Society of Pharmacoepidemiology Global Development
Committee in partnership with the Latin America Drug Utilization
Group and the Medicines Utilization Research in Africa Group was
undertaken. A comprehensive literature review was conducted to
identify local and international DUR publications. A core group of
investigators and experts in DUR reviewed the publications and identified the main methodological challenges and issues. Subsequently,
the group exchanged materials, participated in WebEx discussions,
and reviewed the draft document.
Results: Main issues: (1) Socioeconomic: high unemployment rate with
poor standard of living, socioeconomic inequalities, low literacy levels,
urban segregation, high migration rates, high rates of violent crime
including drug trafficking and possession. (2) Health care‐related: Disparities of social determinants of health, differences in the quality of
public and private health sectors; and epidemiologic transition from
communicable diseases to non‐communicable diseases. Most health
care systems are fragmented with variable access to medical care
and medicines, and substandard record keeping. (3) Drug utilization‐
related: Inappropriate use of medicines including the elderly; limited
infrastructure to reliably collect DU data; over‐prescription of antimicrobials; polypharmacy; high rates of self‐medication; and poor patient
adherence (eg, HIV/AIDS, diabetes mellitus and hypertension). Planning for DUR is affected by the multiplicity of drug distribution channels; trading in sub‐standard, counterfeit medicines and insufficient
quality control centers. Some publications are generated by local
investigators, often suffering of methodological issues such as lack
of representativeness of the population, limited data validity, and small
sample sizes.
Conclusions: There are common challenges for DUR when working
within the LatAm and African regions. Based on our findings, the
group is developing Guidance on Good Practices of Drug Utilization
Research in those regions to assist researchers with issues pertaining
to the planning, conduct, and evaluation of DUR | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.title | Challenges and issues in drug utilization research identified from the Latin American and African regions | en_US |
dc.type | Presentation | en_US |
dc.contributor.researchID | 10730982 - Burger, Johanita Riëtte | |