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dc.contributor.authorDu Preez, Ilse
dc.contributor.authorLuies, Laneke
dc.contributor.authorLoots, Du Toit
dc.date.accessioned2019-04-01T11:29:23Z
dc.date.available2019-04-01T11:29:23Z
dc.date.issued2019
dc.identifier.citationDu Preez, I. et al. 2019. The application of metabolomics toward pulmonary tuberculosis research. Tuberculosis, 115:126-139. [https://doi.org/10.1016/j.tube.2019.03.003]en_US
dc.identifier.issn1472-9792
dc.identifier.urihttp://hdl.handle.net/10394/32088
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1472979218305213
dc.identifier.urihttps://doi.org/10.1016/j.tube.2019.03.003
dc.description.abstractIn the quest to identify novel biomarkers for pulmonary tuberculosis (TB), high-throughput systems biology approaches such as metabolomics has become increasingly widespread. Such biomarkers have not only successfully been used for better disease characterization, but have also provided new insights toward the future development of improved diagnostic and therapeutic approaches. In this review, we give a summary of the metabolomics studies done to date, with a specific focus on those investigating various aspects of pulmonary TB, and the infectious agent responsible, Mycobacterium tuberculosis. These studies, done on a variety of sample matrices, including bacteriological culture, sputum, blood, urine, tissue, and breath, are discussed in terms of their intended research outcomes or future clinical applications. Additionally, a summary of the research model, sample cohort, analytical apparatus and statistical methods used for biomarker identification in each of these studies, is provideden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectBiomarkersen_US
dc.subjectChemometricsen_US
dc.subjectMetabolitesen_US
dc.subjectMetabolomicsen_US
dc.subjectSample matrixen_US
dc.subjectTuberculosisen_US
dc.titleThe application of metabolomics toward pulmonary tuberculosis researchen_US
dc.typeArticleen_US
dc.contributor.researchID20026471 - Du Preez, Ilse
dc.contributor.researchID21637156 - Luies, Laneke
dc.contributor.researchID10799508 - Loots, Du Toit


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