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dc.contributor.authorJansen van Vuren, Esmé
dc.contributor.authorMalan, Leoné
dc.contributor.authorVon Känel, Roland
dc.contributor.authorLammertyn, Leandi
dc.contributor.authorMalan, Nicolaas T.
dc.date.accessioned2019-02-25T11:07:17Z
dc.date.available2019-02-25T11:07:17Z
dc.date.issued2018
dc.identifier.citationJansen van Vuren, E. et al. 2018. Prospective associations between cardiac stress, glucose dysregulation and executive cognitive function in Black men: the Sympathetic activity and ambulatory blood pressure in Africans study. Diabetes and vascular disease research, 16(3):236-243. [https://doi.org/10.1177/1479164118816221]en_US
dc.identifier.issn1479-1641
dc.identifier.issn1752-8984 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/31861
dc.identifier.urihttps://journals.sagepub.com/doi/abs/10.1177/1479164118816221
dc.identifier.urihttps://doi.org/10.1177/1479164118816221
dc.description.abstractObjective: Glucose dysregulation is an independent risk factor for cardiovascular and neurodegenerative disease development through synaptic dysfunction resulting in cognitive decline. The aim of this study was to study the interplay between impaired glycaemic metabolism (hyperglycaemia and insulin resistance), cardiac stress (cardiac troponin T and N-terminal brain natriuretic peptide) and executive cognitive function prospectively, in a bi-ethnic sex cohort. Methods: Black and White teachers (N = 338, aged 20–63 years) from the Sympathetic activity and Ambulatory Blood Pressure in Africans study were monitored over a 3-year period. Fasting blood samples were obtained for cardiac troponin T, N-terminal brain natriuretic peptide, glycated haemoglobin and the homeostatic model assessment-insulin resistance for insulin resistance. The Stroop colour-word conflict test was applied to assess executive cognitive function at baseline. Results: Over the 3-year period, Black men revealed constant high levels of cardiac troponin T (⩾4.2 ng/L), pre-diabetes (glycated haemoglobin > 5.7%) and insulin resistance (homeostatic model assessment-insulin resistance >3). %Δ Glycated haemoglobin was associated with %Δ insulin resistance (p < 0.001) and increases in %ΔN-terminal brain natriuretic peptide (p = 0.02) in Black men only. In the latter, baseline Stroop colour-word conflict test was inversely associated with %Δ cardiac troponin T (p = 0.001) and %Δ insulin resistance levels (p = 0.01). Conclusion: Progressive myocyte stretch and chronic myocyte injury, coupled with glucose dysregulation, may interfere with processes related to interference control in Black menen_US
dc.language.isoenen_US
dc.publisherSageen_US
dc.subjectN-terminal brain natriuretic peptideen_US
dc.subjectCardiac troponinen_US
dc.subjectHyperglycaemiaen_US
dc.subjectInsulin resistanceen_US
dc.subjectCognitionen_US
dc.titleProspective associations between cardiac stress, glucose dysregulation and executive cognitive function in Black men: the Sympathetic activity and ambulatory blood pressure in Africans studyen_US
dc.typeArticleen_US
dc.contributor.researchID22820388 - Jansen van Vuren, Esmé
dc.contributor.researchID10056173 - Malan, Nicolaas Theodor
dc.contributor.researchID10060871 - Malan, Leoné
dc.contributor.researchID25499777 - Von Känel, Roland
dc.contributor.researchID20088310 - Lammertyn, Leandi


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