Itraconazole and thiophanate-methyl fail to clear tadpoles naturally infected with the hypervirulent lineage of Batrachochytrium dendrobatidis
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Date
Authors
Fernández-Loras, Andrés
Garner, Trenton W.J.
Martín-Beyer, Bárbara
Bosch, Jaime
Journal Title
Journal ISSN
Volume Title
Publisher
Inter-Research
Abstract
The emerging infectious disease chytridiomycosis, caused by the fungus Batrachochytrium
dendrobatidis, is a major driver pushing many amphibian species to the brink of
extinction. Substantial efforts to develop effective protocols that use antifungal drugs have had
notable success. Here, we used the antifungal agents itraconazole and thiophanate-methyl, singly
and in combination, in an attempt to treat common midwife toad Alytes obstetricans larvae naturally
infected with the globalized hypervirulent lineage of B. dendrobatidis. Despite the successful
use of itraconazole in a closely related species (A. muletensis), our results show that these anti -
fungal treatments are not always effective and that full clearance of animals cannot be assumed
following treatment
Description
Citation
Fernández-Loras, A. et al. 2018. Itraconazole and thiophanate-methyl fail to clear tadpoles naturally infected with the hypervirulent lineage of Batrachochytrium dendrobatidis. Diseases of aquatic organisms, 131(1):73-78. [https://doi.org/10.3354/dao03282]