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dc.contributor.authorAshton, Melanie M.
dc.contributor.authorHarvey, Brian H.
dc.contributor.authorBerk, Michael
dc.contributor.authorChee, H.
dc.contributor.authorHopwood, Malcolm
dc.date.accessioned2018-11-07T12:40:07Z
dc.date.available2018-11-07T12:40:07Z
dc.date.issued2019
dc.identifier.citationAshton, M. M. et al. 2019. Efficacy of adjunctive Garcinia mangostana Linn (mangosteen) pericarp for bipolar depression: study protocol for a proof-of-concept trial. Brazilian journal of psychiatry, 41(3):245-253. [https://doi.org/10.1590/1516-4446-2018-0114]en_US
dc.identifier.issn1516-4446
dc.identifier.issn1809-452X (Online)
dc.identifier.urihttp://hdl.handle.net/10394/31676
dc.identifier.urihttps://doi.org/10.1590/1516-4446-2018-0114
dc.description.abstractObjective: Bipolar depression is characterized by neurobiological features including perturbed oxidative biology, reduction in antioxidant levels, and a concomitant rise in oxidative stress markers. Bipolar depression manifests systemic inflammation, mitochondrial dysfunction, and changes in brain growth factors. The depressive phase of the disorder is the most common and responds the least to conventional treatments. Garcinia mangostana Linn, commonly known as mangosteen, is a tropical fruit. The pericarp’s properties may reduce oxidative stress and inflammation and improve neurogenesis, making mangosteen pericarp a promising add-on therapy for bipolar depression. Methods: Participants will receive 24 weeks of either 1,000 mg mangosteen pericarp or placebo per day, in addition to their usual treatment. The primary outcome is change in severity of mood symptoms, measured using the Montgomery-A° sberg Depression Rating Scale (MADRS), over the treatment phase. Secondary outcomes include global psychopathology, quality of life, functioning, substance use, cognition, safety, biological data, and cost-effectiveness. A follow-up interview will be conducted 4 weeks post-treatment. Conclusion: The findings of this study may have implications for improving treatment outcomes for those with bipolar disorder and may contribute to our understanding of the pathophysiology of bipolar depression. Clinical trial registration: Australian and New Zealand Clinical Trial Registry, ACTRN12616000028404en_US
dc.language.isoenen_US
dc.publisherABP - Brazilian Psychiatric Associationen_US
dc.subjectGarcinia mangostanaen_US
dc.subjectBipolar disorderen_US
dc.subjectTreatmenten_US
dc.subjectClinical trialen_US
dc.subjectDepressionen_US
dc.titleEfficacy of adjunctive Garcinia mangostana Linn (mangosteen) pericarp for bipolar depression: study protocol for a proof-of-concept trialen_US
dc.typeArticleen_US
dc.contributor.researchID11083417 - Harvey, Brian Herbert


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